AGL-2263 - ≥98% , CAS No.638213-98-6

CAS: 638213-98-6 Cat. No.: A650157 Molecular Weight: 322.27 PubChem CID: 9818584

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

AGL-2263 is an insulin receptor and insulin-like growth factor (IGF) receptor inhibitor

In Vitro

AGL-2263 (5 μM, for 1 h followed by insulin treatment for 24 h) inhibits IR and insulin could still induce phosphorylation of AKT and ERK1/2 after the IR inhibition. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: Granulosa cells. Concentration: 5 μM. Incubation Time: For 1 h followed by insulin treatment for 24 h. Result: Insulin still induced phosphorylation of AKT and ERK1/2 after IR was inhibited by AGL2263.

Form:Solid

IC50& Target:Insulin receptor

Specifications

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

AGL-2263 is an insulin receptor and insulin-like growth factor (IGF) receptor inhibitor.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥98%

Names and Identifiers

• Canonical Smiles: C1=CC2=C(C=C1C=C(C#N)C(=O)C3=CC(=C(C=C3)O)O)NC(=O)O2
• IUPAC Name: (E)-2-(3,4-dihydroxybenzoyl)-3-(2-oxo-3H-1,3-benzoxazol-5-yl)prop-2-enenitrile
• InChIKey: IUGRBTCJEYEDIY-VZUCSPMQSA-N
• INCHI: 1S/C17H10N2O5/c18-8-11(16(22)10-2-3-13(20)14(21)7-10)5-9-1-4-15-12(6-9)19-17(23)24-15/h1-7,20-21H,(H,19,23)/b11-5+
• Isomeric SMILES: C1=CC2=C(C=C1/C=C(\C#N)/C(=O)C3=CC(=C(C=C3)O)O)NC(=O)O2
• PubChem CID: 9818584
• MeSH Entry Terms: AGL 2263;AGL-2263;AGL2263
• Molecular Weight: 322.27

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Phenylpropanoids and polyketides
    • Class Linear 1,3-diarylpropanoids
      • Subclass Chalcones and dihydrochalcones

• Kingdom: Organic compounds
• Superclass: Phenylpropanoids and polyketides
• Class: Linear 1,3-diarylpropanoids
• Subclass: Chalcones and dihydrochalcones
• Intermediate Tree Nodes: Not available
• Direct Parent: Retrochalcones
• Alternative Parents: Cinnamic acids and derivatives Benzoxazolones Aryl ketones Benzoyl derivatives Catechols 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Alpha-branched alpha,beta-unsaturated ketones Heteroaromatic compounds Enones Acryloyl compounds Oxazoles Oxacyclic compounds Azacyclic compounds Nitriles Hydrocarbon derivatives Organic oxides
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Retrochalcone - Cinnamic acid or derivatives - Benzoxazolone - Benzoxazole - Benzoyl - Catechol - Aryl ketone - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Monocyclic benzene moiety - Alpha-branched alpha,beta-unsaturated-ketone - Benzenoid - Heteroaromatic compound - Acryloyl-group - Enone - Oxazole - Azole - Alpha,beta-unsaturated ketone - Ketone - Nitrile - Carbonitrile - Azacycle - Organoheterocyclic compound - Oxacycle - Organonitrogen compound - Cyanide - Organic oxygen compound - Organooxygen compound - Organic nitrogen compound - Organic oxide - Hydrocarbon derivative - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as retrochalcones. These are a form of normal chalcones that are structurally distinguished by the lack of oxygen functionalities at the C2'- and C6'-positions.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: DMSO : 100 mg/mL (310.30 mM; Need ultrasonic)
• Molecular Weight: 322.270 g/mol
• XLogP3: 2.100
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 322.059 Da
• Monoisotopic Mass: 322.059 Da
• Topological Polar Surface Area: 120.000 Ų
• Heavy Atom Count: 24
• Formal Charge: 0
• Complexity: 607.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1