AKT-IN-3 - ≥99% , CAS No.2374740-21-1

CAS: 2374740-21-1 Cat. No.: A647070 Molecular Weight: 526.36

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

AKT-IN-3 (compound E22) is a potent, orally active low hERG blocking Akt inhibitor, with 1.4 nM, 1.2 nM and 1.7 nM for Akt1 , Akt2 and Akt3 , respectively. AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kinases, such as PKA , PKC , ROCK1 , RSK1 , P70S6K , and SGK . AKT-IN-3 (compound E22) induces apoptosis and inhibits metastasis of cancer cells

Form:Solid

IC50& Target:Akt1 1.4 nM (IC 50 ) Akt2 1.2 nM (IC 50 ) Akt3 1.7 nM (IC 50 ) PKA 0.3 nM (IC 50 ) P70S6K 8.9 (IC 50 )

Specifications

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

AKT-IN-3 (compound E22) is a potent, orally active low hERG blocking Akt inhibitor, with 1.4 nM, 1.2 nM and 1.7 nM for Akt1 , Akt2 and Akt3 , respectively. AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kinases, su

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥99%

Names and Identifiers

• Molecular Weight: 526.36

Chemical and Physical Properties

• Solubility: DMSO : ≥ 100 mg/mL (189.98 mM)