ALR-38 , CAS No.241127-61-7

CAS: 241127-61-7 Cat. No.: A1440784 Fórmula: C₁₉H₁₇NO₄ Peso molecular: 323.34

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

ALR-38 is a 5-lipoxygenase ( 5-LOX ) inhibitor (IC 50 : 1.1 μM) with anti-inflammatory activity. ALR-38 effectively reduces ROS levels in neutrophils.

Specifications

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

ANTAGONIST

Nombres e identificadores

• Peso molecular: 323.34

Application Protocols

No validated, item-specific application protocols are provided for ALR-38.

General screening protocol outline (non-item-specific)

• Prepare a concentrated DMSO stock (e.g., 10 mM) if soluble; verify by visual inspection and, if needed, HPLC.
• Dilute into assay buffer to the desired test concentration, keeping final DMSO constant across wells (commonly 0.1–1% v/v).
• Include solvent-only controls and, when feasible, positive and negative control ligands.
• Monitor precipitation or color/fluorescence interference; adjust concentration or detection modality accordingly.

Refer to your assay SOPs; validate any conditions with a small pilot before large screens.

Biological Roles

No biological target, pathway, or mechanistic information is provided for ALR-38. Accordingly, specific biological roles cannot be ascribed.

General considerations for library compounds (non-item-specific)

• Compounds in discovery libraries may interact with diverse protein classes (enzymes, receptors, transporters) depending on their chemotypes. Without structure, assume no defined target specificity.
• Prior to extensive biology, confirm purity and verify the absence of common assay interferences (aggregation, fluorescence, redox activity). Employ counterscreens and orthogonal readouts.
• Stability in assay media (hydrolysis, oxidation, photolysis) should be assessed empirically for any active hit.

Research use notice

• For research use only. Not intended for diagnostic, therapeutic, or clinical applications.

Buffer Applications

ALR-38 is a small organic compound, not a buffering agent. No buffer capacity or pKa data are provided.

• Buffer use: Not typically applicable. If formulating assay solutions, prepare compound stocks in DMSO (general practice) and dilute into an appropriate biological buffer (e.g., PBS, HEPES) validated for the assay.
• Any pH-dependent behavior or solubility effects should be determined empirically once structural information is available.

Green Alternatives

ALR-38 is not a process solvent; however, dissolution media and handling solvents can influence environmental footprint.

General guidance for greener handling (not item-specific)

• Stock solutions: Prefer DMSO over high-boiling dipolar aprotics like NMP/DMF when feasible; DMSO offers lower toxicity and better biodegradability.
• Dilution: Use water-based buffers with minimal co-solvent for assays. Keep DMSO ≤0.5–1% v/v where biology permits to reduce solvent load.
• Workup/cleanup: Replace chlorinated solvents for vial washing or sample prep with ethyl acetate or isopropanol when compatible.

Illustrative comparison (literature-general)

• DMF vs DMSO: DMSO typically offers comparable solvency for drug-like molecules with a better EHS profile; DMF is classified as a reproductive toxin in many jurisdictions.
• NMP vs alternatives: Consider Cyrene or propylene carbonate in method development, though compatibility with bioassays must be validated.

Waste minimization

• Plan aliquots to avoid repeated thaw–freeze cycles and consequent disposals. Consolidate compatible organic wastes and segregate halogenated streams to facilitate responsible disposal.

Pharmaceutical Uses

No pharmacopeial status, excipient role, or formulation use is specified for ALR-38. This item is supplied strictly for research use only.

• Not for human or veterinary use. No claims are made regarding safety, efficacy, or suitability for GMP manufacturing.
• If a hit progresses toward pre-formulation studies, obtain full identity, impurity profile, polymorph/solid-form data, and stability protocols under ICH conditions—none of which are specified for this catalog entry.

Physical Properties

No item-specific physico-chemical parameters are provided for ALR-38 in the Product Data.

• Appearance: Not specified for this item; refer to CoA/Spec Sheet.
• Melting point: Not specified for this item; refer to CoA/Spec Sheet.
• Boiling point: Not specified for this item; refer to CoA/Spec Sheet.
• Density: Not specified for this item; refer to CoA/Spec Sheet.
• Refractive index: Not specified for this item; refer to CoA/Spec Sheet.
• pKa/logP/logD: Not specified for this item; refer to CoA/Spec Sheet.
• Solubility: Not specified for this item; refer to CoA/Spec Sheet.

Practical guidance (general, not item-specific)

• Library members are commonly supplied as dry solids or as DMSO concentrates (e.g., 10 mM). If form is unknown, visually inspect vial and consult CoA.
• Typical dissolution solvents for diverse drug-like compounds include DMSO (primary), DMF, ethanol, or aqueous buffers with co-solvent. Begin with DMSO, then serially dilute into assay buffer to minimize precipitation.
• If hygroscopicity or light sensitivity is suspected (common for heteroaromatics/azo/anthracenones), handle under dry, subdued-light conditions. Confirm by CoA.

All specifications for this item are “Not specified for this item; refer to CoA/Spec Sheet” unless otherwise stated above.

Quality and Grades

• Grade/purity: Not specified for this item; refer to CoA/Spec Sheet.

Interpretation and guidance

• For screening compounds, typical deliverables include identity confirmation (LC–MS and/or 1H NMR), purity by HPLC/UPLC (commonly ≥95% for screening), and salt/form info. Because this listing does not specify, verify the Certificate of Analysis prior to quantitative biology or SAR work.
• UV-Vis background, residual solvents, and water content can impact assay interference and stability. When grade is unspecified:
  • Run an intake QC check: LC–MS for identity, analytical HPLC for purity/peak homogeneity, and a quick 1H NMR if structure becomes available.
  • For photoactive moieties (unknown here), confirm absence of significant absorbance at assay wavelengths to reduce false positives.
• If a stabilizer is present (antioxidant/acid additive), it will be indicated on the CoA; absence of such info here means stabilizer use is not specified.

Documentation

• For regulated or quantitative research, request: CoA, Spec Sheet, SDS, and if needed, an analytical package (chromatogram, MS, NMR). This ensures fit-for-purpose selection of the lot for your application.

Reaction and Applications

This product is positioned as a small-molecule library member for screening and discovery workflows rather than as a general-purpose reagent. Without a disclosed structure, specific synthetic or reaction applications cannot be assigned.

Applicable research uses (general, non-item-specific)

• Primary/secondary screening: Evaluate as part of a chemical library in biochemical or cell-based assays to identify activity profiles. Maintain consistent solvent controls.
• Profiling and deconvolution: If activity is observed, pursue orthogonal counterscreens to rule out assay interference (e.g., redox cycling, aggregation, fluorescence quenching). Use PAINS and aggregator filters once structure becomes available.
• Hit confirmation: Source a fresh lot, verify identity/purity by LC–MS/HPLC, and determine basic physchem properties (solubility, stability in assay media).

Not applicable here

• Named synthetic reactions or catalyst roles cannot be discussed without structural information.

All statements herein are general guidance and not item-specific specifications.

Reaction Conditions

Item-specific reaction conditions are not applicable because the structure and functional groups of ALR-38 are undisclosed.

General note

• If subsequent use as a reagent or intermediate is intended, determine: solvent compatibility, thermal stability (DSC/TGA), and sensitivity to moisture/air/light. Establish small-scale test reactions under inert atmosphere if instability is suspected.
• For analytical method development (not a chemical reaction), LC–MS with a water/acetonitrile + 0.1% formic acid gradient is a common starting point for drug-like molecules; adjust based on retention/ionization behavior.

Safety and Handling

GHS information for ALR-38 is not provided in the Product Data. Always consult the SDS for authoritative hazard classification and response measures.

• Signal word: Not specified for this item; refer to SDS.
• Hazard statements (H-codes): Not specified for this item; refer to SDS.
• Pictograms: Not specified for this item; refer to SDS.
• GHS classification: Not specified for this item; refer to SDS.

General laboratory precautions (good practice for unknown small molecules)

• PPE: Lab coat, safety glasses, and suitable gloves (e.g., nitrile). Use additional splash/respiratory protection if aerosolization or heating may occur.
• Engineering controls: Handle in a fume hood to avoid inhalation of dust/vapors. Use secondary containment to prevent spills.
• Incompatibilities: In the absence of structure, segregate from strong oxidizers, strong acids/bases, and reducing agents. Avoid contact with ignition sources.
• First aid (overview): If on skin/eyes, rinse with water for 15 minutes; if inhaled, move to fresh air; if ingested, rinse mouth. Seek medical attention; bring SDS.
• Spill response: Avoid dust, absorb liquids with inert material, collect residues for disposal per local regulations. Decontaminate surfaces.
• Waste: Dispose as organic laboratory chemical waste unless SDS indicates otherwise.

Storage notes

• Store at −20°C as specified. Keep container tightly closed, protected from moisture and light, and clearly labeled. Minimize freeze–thaw by aliquoting when feasible.

Solvent Selection

Because the structure and polarity of ALR-38 are not disclosed, solvent choice should follow a staged, property-agnostic approach typical for diverse small molecules.

Recommended workflow (general guidance)

• Primary stock: DMSO is the default for screening compounds due to broad solvency and compatibility with biological assays at ≤1% v/v.
• Alternatives and escalation:
  • If insoluble in DMSO at target concentration, warm gently (≤40°C) and sonicate; avoid prolonged heating.
  • Consider DMF or NMP for difficult solutes (later dilute into DMSO or buffer).
  • For less polar solids, try ethanol or isopropanol; for very nonpolar, MTBE or toluene for analytical prep, then back-extract or solvent-swap to DMSO.
• Aqueous use: Dilute DMSO stocks into PBS/assay buffer last, with vigorous mixing to minimize precipitation; include 0.01–0.1% nonionic surfactant only if assay-compatible.

Notes

• Solubility, dielectric constants, and logP are not specified for this item; develop empirically with small-scale tests.
• Filter through 0.22 μm if particulates remain and filtration is compatible with the analyte.
• Record the final solvent composition in assay metadata to ensure reproducibility.

Storage and Reconstitution

Storage

• Store at −20°C (as specified in Product Data). Keep tightly sealed in original container. Protect from moisture and light. Use desiccant and inert gas backfill if the compound is known or suspected to be air/moisture sensitive (information not specified for this item).
• Shipped in an ice chest with ice pads to maintain a low-temperature chain. Inspect upon receipt; if warm, allow to equilibrate to room temperature in sealed packaging to prevent condensation before opening.

Reconstitution (general guidance, not item-specific)

• Solvent: Begin with anhydrous DMSO to prepare a concentrated stock solution. If insoluble, consider DMF or ethanol; confirm assay compatibility before use.
• Concentration: Common screening stocks are 10–50 mM; determine solubility empirically.
• Aliquoting: Prepare single-use aliquots to minimize freeze–thaw cycles. Store aliquots at −20°C or below in amber vials if light sensitivity is suspected.
• Thawing: Warm to room temperature before opening to avoid moisture ingress; mix thoroughly after thaw. Do not vortex if foaming may influence assays.

Specifications not provided

• Appearance, purity, molecular weight, stabilizers, and exact solubility: Not specified for this item; refer to CoA/Spec Sheet.

Research use only: Not for human or veterinary use.

Structure and Identity

ALR-38 (SKU A1440784) is listed as a small-molecule library member for research screening. The structural details for this specific catalog entry are not disclosed in the Product Data.

• CAS: 241127-61-7 (as provided)
• Chemical name: Not specified for this item; refer to CoA/Spec Sheet.
• Molecular formula: Not specified for this item; refer to CoA/Spec Sheet.
• Molecular weight: Not specified for this item; refer to CoA/Spec Sheet.
• SMILES: Not specified for this item; refer to CoA/Spec Sheet.
• InChIKey: Not specified for this item; refer to CoA/Spec Sheet.
• Synonyms: Not specified for this item; refer to CoA/Spec Sheet.

Structural description

• Item-specific functional groups, ring systems, and stereochemistry: Not specified for this item; refer to CoA/Spec Sheet.
• 2D structure: Not provided in Product Data. If needed for cheminformatics, request the SD file or structure record from support.

Notes

• Category path indicates inclusion in a small-molecule/compound library (screening collection). Absent structure, treat as a generic organic research compound and consult the SDS/CoA for definitive identity attributes before use in regulated workflows.

Synthetic Utility

Without a disclosed structure or functional group information, synthetic transformations and reactivity patterns for ALR-38 cannot be discussed.

• Not applicable: Named reactions, protecting-group strategies, or cross-coupling suitability require knowledge of functional handles (halides, boronates, acids, amines, etc.), which are not provided.
• If ALR-38 is to be used as a starting material or intermediate, request detailed structural data and CoA to plan appropriate reaction pathways and safety assessments.

Target Specificity

No target, binding partner, or selectivity profile is provided for ALR-38. This catalog entry does not include antibody- or probe-specific details such as antigen, clone, or species reactivity.

• For screening outcomes, define target specificity experimentally and confirm with orthogonal assays once the structure and high-quality reference material are secured.