ALS-8112 - 10mM in DMSO , CAS No.1445379-92-9

CAS: 1445379-92-9 Cat. No.: A655621 Fórmula: C₁₀H₁₃ClFN₃O₄ Peso molecular: 293.68 PubChem CID: 71621663

CALIDAD & PUREZA 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

ALS-8112 is a potent and selective respiratory syncytial virus ( RSV ) polymerase inhibitor. The 5'-triphosphate form of ALS-8112 inhibits RSV polymerase with an IC 50 of 0.02 μM.

In Vitro

The 5'-triphosphate form of ALS-8112 (ALS-8112-TP) is the active form of the drug and selectively inhibits RSV polymerase through chain termination of RNA synthesis. ALS-008112 enters various types of epithelial cells in the respiratory tract and is subsequently phosphorylated to form an intracellular nucleoside triphosphate with a half-life of approximately 29 hours. The nucleoside triphosphate analogue inhibits RSV replication by means of chain termination. ALS-8112 is a pan-strain inhibitor of RSV replication in vitro . The RNA transcription activity of the RSV–RNP complex is dose-proportionally inhibited by ALS-8112-TP with an IC 50 of 0.020 ± 0.008 μM . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IC50: 0.02 μM ( RSV )

Especificaciones

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

ALS-8112 is a potent and selective respiratory syncytial virus ( RSV ) polymerase inhibitor. The 5'-triphosphate form of ALS-8112 inhibits RSV polymerase with an IC 50 of 0.02 μM.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Tipo de acción

INHIBITOR

Nombres e identificadores

Isómeros SMILES

C1=CN(C(=O)N=C1N)[C@H]2[C@@H]([C@@H]([C@](O2)(CO)CCl)O)F

CAS alternativo

1445379-92-9

PubChem CID

71621663

Peso molecular

293.68