AMG PERK 44 - ≥95% , CAS No.1883548-84-2

CAS: 1883548-84-2 Cat. No.: A286749 Molecular Weight: 561.07

GRADE & PURITY ≥95%

Synonyms

4-[2-Amino-4-methyl-3-(2-methyl-6-quinolinyl)benzoyl]-1,2-dihydro-1-methyl-2,5-diphenyl-3H-pyrazol-3-one hydrochloride

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

AMG PERK 44 is an orally effective, highly selective PERK inhibitor with an IC50 of 6 nM. The selectivity of AMG PERK 44 for PERK is 1000 and 160 times higher than that of GCN2 (IC50=7300 nM) and B-Raf (IC50>1000 nM), respectively. AMG PERK 44 can induce autophagy.

Specifications

Synonyms

4-[2-Amino-4-methyl-3-(2-methyl-6-quinolinyl)benzoyl]-1, 2-dihydro-1-methyl-2, 5-diphenyl-3H-pyrazol-3-one hydrochloride

Specifications & Purity

≥95%

Biochemical and Physiological Mechanisms

Potent and selective PERK inhibitor (IC50= 6 nM). Exhibits >160-fold selectivity for PERK over B-Raf and GCN2, as well as a panel of 387 other kinases. Orally bioavailable.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥95%

Names and Identifiers

• Canonical Smiles: CC1=C(C(=C(C=C1)C(=O)C2=C(N(N(C2=O)C3=CC=CC=C3)C)C4=CC=CC=C4)N)C5=CC6=C(C=C5)N=C(C=C6)C.Cl
• IUPAC Name: 4-[2-amino-4-methyl-3-(2-methylquinolin-6-yl)benzoyl]-1-methyl-2,5-diphenylpyrazol-3-one;hydrochloride
• InChIKey: RNAKBTDDCHJCMT-UHFFFAOYSA-N
• INCHI: 1S/C34H28N4O2.ClH/c1-21-14-18-27(31(35)29(21)25-17-19-28-24(20-25)16-15-22(2)36-28)33(39)30-32(23-10-6-4-7-11-23)37(3)38(34(30)40)26-12-8-5-9-13-26;/h4-20H,35H2,1-3H3;1H
• Molecular Weight: 561.07
• Reaxy-Rn: 27969561
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=27969561&ln=

Chemical and Physical Properties

• Solubility: Solvent:DMSO, Max Conc. mg/mL: 11.22, Max Conc. mM: 20
• Sensitivity: Moisture sensitive