Atuliflapon - 10mM in DMSO , CAS No.2041075-86-7

CAS: 2041075-86-7 Cat. No.: A656323 Fórmula: C₂₄H₂₆N₆O₃ Peso molecular: 446.50 PubChem CID: 122678117

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Atuliflapon (AZD5718) is an orally active inhibitor of FLAP (5‑Lipoxygenase activating protein) , with an IC 50 of 2 nM. Atuliflapon is used in the study for coronary artery disease

In Vitro

Atuliflapon demonstrates a dose dependent and greater than 90% suppression of leukotriene production over 24 h. Atuliflapon exhibits an IC 50 of 39 nM for LTB 4. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Atuliflapon exhibits t1/2 of 0.45 h and 2.1 h in rat and dog by iv injection, respectively . Atuliflapon shows no inhibition of 5-LO pathway activity in rodent blood . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IC50: 2 nM (FLAP)

Specifications

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Atuliflapon (AZD5718) is an orally active inhibitor of FLAP (5‑Lipoxygenase activating protein) , with an IC 50 of 2 nM. Atuliflapon is used in the study for coronary artery disease.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Tipo de acción

INHIBITOR

Nombres e identificadores

Isómeros SMILES

CC1=CC(=NN1)C2=CC=C(C=C2)C(=O)[C@@H]3CCCC[C@H]3C(=O)NC4=C5C(=O)NCCN5N=C4

CAS alternativo

2041075-86-7

PubChem CID

122678117

Términos de entrada MeSH

AZD5718

Peso molecular

446.50

Objetivos asociados (humanos)

ALOX5AP Tchem Arachidonate 5-lipoxygenase-activating protein (0 Activities)

Discover Target: ALOX5AP

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)