Bezisterim - Moligand™, 10 mM in DMSO , CAS No.1001100-69-1

CAS: 1001100-69-1 Cat. No.: B1494053 Fórmula: C₂₁H₃₀O₃ Peso molecular: 330.46 Número EC: 880-101-1 PubChem CID: 16739648

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Bezisterim (HE 3286; NE-3107) is a synthetic derivative of a natural anti-inflammatory steroid, β-AET. Bezisterim is an orally active partial NF-κB inhibitor. HE3286 reduces proinflammatory signals, including IL-6 and matrix metallopeptidase 3. Bezisterim freely penetrates the blood brain barrierin mice. Bezisterim can be used for the research of the ulcerative colitis, arthritis, experimental autoimmune encephalomyelitis. Bezisterim is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Specifications

Especificaciones y pureza

Moligand™, 10 mM in DMSO

Condiciones de almacenamiento de almacenamiento

Desiccated,Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Nombres e identificadores

• Isómeros SMILES: C[C@]12CC[C@@H](CC1=C[C@@H]([C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@]4(C#C)O)C)O)O
• PubChem CID: 16739648
• Peso molecular: 330.46

Referencias

1. Kaili Liu, Jianli Li, Zhiwei Sun, Yuheng Sun, Xuerui Zhang, Yang Sui, Zhongyuan Qu, Xiang Zou.  (2025)  Chelidonine-induced inhibition of FBP1 disrupts M2 macrophage polarization and attenuates breast cancer.  PHYTOMEDICINE,      [PMID:41175579] [10.1016/j.phymed.2025.157451]

2. Yin Xuanying, Qiu Jinmei, Cheng Guowang, Wu Jiaxin, Wang Chen, Zheng Chunye, Huang Shuiqing, Chen Tongkai.  (2025)  Biomimetic nanodelivery system with simultaneous blood–brain barrier-crossing and neuroprotective abilities for anti-parkinsonian therapy.  Chinese Medicine,  20  (1): (1-24).  [PMID:41204267] [10.1186/s13020-025-01239-2]

3. Zhongyuan Qu, Huimin Li, Fajing Qiang, Kaili Liu, Shuang Wu, Jianli Li, Xiang Zou.  (2025)  Regulation of inflammation by Chaihu-Shugan-San: Targeting the IL-17/ NF-κB pathway to combat breast cancer-related depression.  PHYTOMEDICINE,      [PMID:40382939] [10.1016/j.phymed.2025.156836]

Preguntas frecuentes

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1001100-69-1, the molecular formula is C21H30O3, and the molecular weight is 330.46 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.