BF-170 hydrochloride - ≥98%(HPLC) , CAS No.22191-97-5

CAS: 22191-97-5 Cat. No.: B168718 Fórmula: C₁₅H₁₂N₂ · HCl Peso molecular: 256.73 Número EC: 636-575-5

GRADE & PURITY ≥98%(HPLC)

Synonyms

22191-97-5|4-quinolin-2-ylaniline|Benzenamine, 4-(2-quinolinyl)-|4-(Quinolin-2-yl)aniline|2-(4-Aminophenyl)quinoline|(4-Quinolin-2-ylphenyl)amine|NSC168387|Paraaminophenylchinolin|2-(4-Amino)phenylquinoline|SCHEMBL1298412|CHEMBL1411717|AKOS004118002|NSC-1

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Specifications

Sinónimos

22191-97-5 | 4-quinolin-2-ylaniline | Benzenamine, 4-(2-quinolinyl)- | 4-(Quinolin-2-yl)aniline | 2-(4-Aminophenyl)quinoline | (4-Quinolin-2-ylphenyl)amine | NSC168387 | Paraaminophenylchinolin | 2-(4-Amino)phenylquinoline | SCHEMBL1298412 | CHEMBL1411717 | AKOS004118002 | NSC-1

Especificaciones y pureza

≥98%(HPLC)

Mecanismos bioquímicos y fisiológicos

BF-170 is a new probe for neurofibrillary tangles (tau fibrils). It exhibits greater binding affinity to tau than to Aβ fibrils, EC50 = 221 nM vs. EC50 = 786 nM (Ki for Aβ > 5,000 nM). BF-170 demonstrates fast clearance from the brain; clearly visualizes

Condiciones de almacenamiento de almacenamiento

Protected from light,Store at -20°C,Argon charged

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥98%(HPLC)

Nombres e identificadores

Pubchem Sid

504758368

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504758368

Sonrisas canónicas

C1=CC=C2C(=C1)C=CC(=N2)C3=CC=C(C=C3)N

IUPAC Name

4-quinolin-2-ylaniline

InChIKey

PWLMSCCFNGGPGM-UHFFFAOYSA-N

INCHI

1S/C15H12N2/c16-13-8-5-12(6-9-13)15-10-7-11-3-1-2-4-14(11)17-15/h1-10H,16H2

Isómeros SMILES

C1=CC=C2C(=C1)C=CC(=N2)C3=CC=C(C=C3)N

WGK Alemania

3

Peso molecular

256.73

Reaxy-Rn

160325

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=160325&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Quinolines and derivatives
      • Subclass Phenylquinolines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Quinolines and derivatives
• Subclass: Phenylquinolines
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenylquinolines
• Alternative Parents: Phenylpyridines Aniline and substituted anilines Heteroaromatic compounds Azacyclic compounds Primary amines Organopnictogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Phenylquinoline - 2-phenylpyridine - Aniline or substituted anilines - Benzenoid - Pyridine - Monocyclic benzene moiety - Heteroaromatic compound - Azacycle - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Primary amine - Organonitrogen compound - Amine - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as phenylquinolines. These are heterocyclic compounds containing a quinoline moiety substituted with a phenyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

ARSA Tbio Cerebroside-sulfatase (655 Activities)

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HEK293 (82097 Activities)

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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

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NPC1 Tchem Niemann-Pick C1 protein (18985 Activities)

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RAB9A Tbio Ras-related protein Rab-9A (22488 Activities)

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CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)

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ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)

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HSPA5 Tchem 78 kDa glucose-regulated protein (3319 Activities)

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ATXN2 Tbio Ataxin-2 (54410 Activities)

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RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)

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MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)

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Objetivos asociados (no humanos)

Saccharomyces cerevisiae (19171 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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pfk 6-phospho-1-fructokinase (7870 Activities)

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Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

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Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

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Rorc Nuclear receptor ROR-gamma (89407 Activities)

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fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)

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Mecanismos de acción

Propiedades químicas y físicas

• Sensibilidad: light sensitive
• Peso molecular: 220.270 g/mol
• XLogP3: 3.200
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 220.1 Da
• Monoisotopic Mass: 220.1 Da
• Topological Polar Surface Area: 38.900 Ų
• Heavy Atom Count: 17
• Formal Charge: 0
• Complexity: 245.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1