BI-2545 - 10mM in DMSO , CAS No.2162961-71-7

CAS: 2162961-71-7 Cat. No.: B655755 Molecular Weight: 527.42

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

BI-2545 is a potent autotaxin (ATX) inhibitor that significantly reduces LPA, with IC 50 s of 2.2 nM and 3.4 nM for human ATX and rat ATX, respectively

In Vitro

BI-2545 displays good potency in the LPA and rat whole blood assay with IC 50 s of 29 nM and 96 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BI-2545 (10 mg/kg; p.o.) has high and sustained in vivo efficacy in reducing LPAs . BI-2545 (10 mg/kg; p.o.) has a half-life of t 1/2 =3.4 hours . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Rat Dosage: 10 mg/kg Administration: Oral administration Result: Reduces the sum of the plasma LPA species up to 90%.

IC50& Target:C50: 2.2 nM (human ATX), 3.4 nM (rat ATX)

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

BI-2545 is a potent autotaxin (ATX) inhibitor that significantly reduces LPA, with IC 50 s of 2.2 nM and 3.4 nM for human ATX and rat ATX, respectively.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Molecular Weight: 527.42