Biotin-PEG2-azide - ≥98% , CAS No.1910803-72-3

CAS: 1910803-72-3 Cat. No.: B595446 Molecular Weight: 400.5

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Biotin-PEG2-azide is PEG derivative containing a biotin group and an azide group. The azide group can react with either alkyne moiety in Cu(I)-catalyzed Click Chemistry reaction or DBCO moiety in copper-free Click Chemistry reaction to form a stable triazole linkage. The hydrophilic PEG spacer increases solubility in aqueous media of the molecules conjugated to the biotin compound. It also helps to minimize steric hindrance involved with the binding to avidin molecules.

Specifications

Specifications & Purity

≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Canonical Smiles: C1C2C(C(S1)CCCCC(=O)NCCOCCOCCN=[N+]=[N-])NC(=O)N2
• IUPAC Name: N-[2-[2-(2-azidoethoxy)ethoxy]ethyl]-5-(2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl)pentanamide
• InChIKey: OVEZMVONEJMGLZ-UHFFFAOYSA-N
• INCHI: 1S/C16H28N6O4S/c17-22-19-6-8-26-10-9-25-7-5-18-14(23)4-2-1-3-13-15-12(11-27-13)20-16(24)21-15/h12-13,15H,1-11H2,(H,18,23)(H2,20,21,24)
• Molecular Weight: 400.5
• Reaxy-Rn: 50740936
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=50740936&ln=

Chemical and Physical Properties

• Solubility: Solubility in Water, DMSO, DCM, DMF

References

1. Jia Mutian, Wang Yuanyuan, Wang Jie, Qin Danhui, Wang Mengge, Chai Li, Fu Yue, Zhao Chunyuan, Gao Chengjiang, Jia Jihui, Zhao Wei.  (2023)  Myristic acid as a checkpoint to regulate STING-dependent autophagy and interferon responses by promoting N-myristoylation.  Nature Communications,  14  (1): (1-12).  [PMID:36750575] [10.1038/s41467-023-36332-3]