BMS-984923 - Moligand™, ≥99% , CAS No.1375752-78-5

CAS: 1375752-78-5 Cat. No.: B647879 Fórmula: C₂₂H₁₅ClN₂O₂ Peso molecular: 374.82 PubChem CID: 69084898

GRADE & PURITY Moligand™, ≥99%

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

BMS-984923, a potent mGluR5 silent allosteric modulator (SAM), with exquisite binding affinity (K i = 0.6 nM), exhibits good oral bioavailability and BBB penetration. BMS-984923 potently inhibits the PrPC-mGluR5 interaction and prevents pathological Aβo signaling without affecting physiological glutamate signaling.

In Vivo

BMS-984923 (7.5 mg/kg or 15 mg/kg, oral gavage, once) exhibits good oral bioavailability and BBB penetration . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57Bl6J male mice . Dosage: 7.5 mg/kg or 15 mg/kg (Pharmacokinetic Analysis) Administration: Oral gavage, once. Result: The plasma concentration exceeded 2 μM at 10 hr. Brain concentrations were nearly as high as plasma concentrations when measured 3 hr after a 7.5 mg/kg oral dose

Form:Solid

Specifications

Especificaciones y pureza

Moligand™, ≥99%

Mecanismos bioquímicos y fisiológicos

BMS-984923, a potent mGluR5 silent allosteric modulator (SAM), with exquisite binding affinity (K i = 0.6 nM), exhibits good oral bioavailability and BBB penetration. BMS-984923 potently inhibits the PrPC-mGluR5 interaction and prevents pathological Aβo s

Condiciones de almacenamiento de almacenamiento

Protected from light,Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

MODULATOR

Pureza

≥99%

Nombres e identificadores

• Pubchem Sid: 528763484
• Isómeros SMILES: C1=CC=C(C=C1)C#CC2=CC(=CN=C2)[C@@H]3[C@H](OC(=O)N3)C4=CC=CC=C4Cl
• PubChem CID: 69084898
• Peso molecular: 374.82

Objetivos asociados (humanos)

GRM5 Tchem Metabotropic glutamate receptor 5 (1 Activities)

Discover Target: GRM5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: DMSO : 50 mg/mL (133.40 mM; Need ultrasonic)
• Sensibilidad: Light sensitive，Moisture sensitive.