Bobcat339 hydrochloride - ≥99% , CAS No.2436747-44-1

CAS: 2436747-44-1 Cat. No.: B651497 Fórmula: C₁₆H₁₃Cl₂N₃O Peso molecular: 334.20 PubChem CID: 138319672

CALIDAD & PUREZA ≥99%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Descripción general

Bobcat339 hydrochloride is a potent and selective cytosine-based inhibitor of TET enzyme , with the IC 50 s of 33 μM and 73 μM for TET1 and TET2 , respectively. Bobcat339 hydrochloride is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription

In Vitro

Bobcat339 (10 μM; 24 hours) significantly reduces global 5hmC levels by inhibiting TET enzyme function in HT-22 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:TET1 33 μM (IC 50 ) TET2 73 μM (IC 50 )

Especificaciones

Especificaciones y pureza

≥99%

Mecanismos bioquímicos y fisiológicos

Bobcat339 hydrochloride is a potent and selective cytosine-based inhibitor of TET enzyme , with the IC 50 s of 33 μM and 73 μM for TET1 and TET2 , respectively. Bobcat339 hydrochloride is useful to the field of epigenetics and serves as a starting point f

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C,Desiccated

Enviado en

Wet ice

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Pureza

≥99%

Nombres e identificadores

Sonrisas canónicas

C1=CC=C(C=C1)C2=CC(=CC=C2)N3C=C(C(=NC3=O)N)Cl.Cl

IUPAC Name

4-amino-5-chloro-1-(3-phenylphenyl)pyrimidin-2-one;hydrochloride

InChIKey

ZOMPKMMOPYMRIB-UHFFFAOYSA-N

INCHI

1S/C16H12ClN3O.ClH/c17-14-10-20(16(21)19-15(14)18)13-8-4-7-12(9-13)11-5-2-1-3-6-11;/h1-10H,(H2,18,19,21);1H

PubChem CID

138319672

Peso molecular

334.20

Propiedades químicas y físicas

• Solubilidad: DMSO : 130 mg/mL (388.99 mM; Need ultrasonic) H2O : 0.1 mg/mL (0.30 mM; Need ultrasonic)