BSJ-04-122 - ≥99% , CAS No.2513289-74-0

CAS: 2513289-74-0 Cat. No.: B649627 Molecular Weight: 313.74

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

BSJ-04-122 is a covalent MKK4/7 dual inhibitor. BSJ-04-122 inhibits MKK4 and MKK7 with IC 50 values of 4 nM and 181 nM, respectively. BSJ-04-122 can be used for the research of cancer

In Vitro

BSJ-04-122 has inhibitory activity for MKK4 and MKK7 with IC 50 values of 4 nM and 181 nM, respectively. BSJ-04-122 (1, 5, 10 μM; 6 h) induces robust reduction of JNK phosphorylation. BSJ-04-122 (0, 1.25, 2.5, 5, 10, 20 μM; 72 h) shows enhanced antiproliferative effects when combination with JNK-IN-8. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: MDA-MB-231 cells Concentration: 1, 5, 10 μM Incubation Time: 6 h Result: Significantly decreased levels of T183/Y185 pJNK at 5 μM. Cell Proliferation AssayCell Line: MDA-MB-231 cells Concentration: 1-100 μM; 0, 1.25, 2.5, 5, 10, 20 μM Incubation Time: 72 h Result: Exhibited antiproliferative effects when combination with JNK-IN-8 in MDA-MB-231 cells.

Form:Solid

IC50& Target:IC50: 4 nM (MKK4),181 nM (MKK7)

Specifications

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

BSJ-04-122 is a covalent MKK4/7 dual inhibitor. BSJ-04-122 inhibits MKK4 and MKK7 with IC 50 values of 4 nM and 181 nM, respectively. BSJ-04-122 can be used for the research of cancer.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥99%

Names and Identifiers

• Canonical Smiles: C=CC(NC1=CC=CC=C1NC2=C3C(NC=C3Cl)=NC=N2)=O
• Molecular Weight: 313.74