BTD - Moligand™, ≥98%(HPLC) , Activator of TRPC5, CAS No.896684-04-1, Activator of TRPC5

CAS: 896684-04-1 Cat. No.: B288219 Fórmula: C₂₄H₃₃N₃O₄S Peso molecular: 459.61 PubChem CID: 46369355

GRADE & PURITY Moligand™, ≥98%(HPLC)

Synonyms

6-Methyl-N-[3-(tricyclo[3.3.1.13,7]dec-1-yloxy)propyl]-4H-1,2,4-benzothiadiazine-3-propanamide-1,1-dioxide

Storage

Conservar a -20°C

Shipped In

Hielera + almohadillas de hielo

Specifications

Sinónimos

6-Methyl-N-[3-(tricyclo[3.3.1.13,7]dec-1-yloxy)propyl]-4H-1,2,4-benzothiadiazine-3-propanamide-1,1-dioxide

Especificaciones y pureza

Moligand™, ≥98%(HPLC)

Mecanismos bioquímicos y fisiológicos

Activador selectivo de TRPC5 (EC50= 1,4 μM en un ensayo de afluencia de calcio, 1,3 μM en un ensayo de patch clamp de células enteras). Muestra una selectividad >14,5 veces mayor para TRPC5 que para otros canales TRP (EC50= 20,6 μM para TRPM8). También ac

Condiciones de almacenamiento de almacenamiento

Conservar a -20°C

Enviado en

Hielera + almohadillas de hielo

Grado

Moligand™

Tipo de acción

ACTIVATOR

Mecanismo de acción

Activator of TRPC5

Pureza

≥98%(HPLC)

Nombres e identificadores

• Sonrisas canónicas: CC1=CC2=C(C=C1)S(=O)(=O)N=C(N2)CCC(=O)NCCCOC34CC5CC(C3)CC(C5)C4
• IUPAC Name: N-[3-(1-adamantyloxy)propyl]-3-(6-methyl-1,1-dioxo-4H-1λ6,2,4-benzothiadiazin-3-yl)propanamide
• InChIKey: YXADKMPRWFBOHW-UHFFFAOYSA-N
• INCHI: 1S/C24H33N3O4S/c1-16-3-4-21-20(9-16)26-22(27-32(21,29)30)5-6-23(28)25-7-2-8-31-24-13-17-10-18(14-24)12-19(11-17)15-24/h3-4,9,17-19H,2,5-8,10-15H2,1H3,(H,25,28)(H,26,27)
• Isómeros SMILES: CC1=CC2=C(C=C1)S(=O)(=O)N=C(N2)CCC(=O)NCCCOC34CC5CC(C3)CC(C5)C4
• PubChem CID: 46369355
• Peso molecular: 459.61

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Thiadiazines
      • Subclass Benzothiadiazines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Thiadiazines
• Subclass: Benzothiadiazines
• Intermediate Tree Nodes: Not available
• Direct Parent: 1,2,4-benzothiadiazine-1,1-dioxides
• Alternative Parents: Imidolactams Fatty amides Benzenoids Organosulfonic acids and derivatives Secondary carboxylic acid amides Dialkyl ethers Azacyclic compounds Amidines Organic oxides Hydrocarbon derivatives Carbonyl compounds Amines
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: 1,2,4-benzothiadiazine-1,1-dioxide - Fatty amide - Benzenoid - Imidolactam - Fatty acyl - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Carboxamide group - Secondary carboxylic acid amide - Ether - Dialkyl ether - Carboxylic acid derivative - Amidine - Azacycle - Organic oxide - Organic oxygen compound - Amine - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Carbonyl group - Hydrocarbon derivative - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as 1,2,4-benzothiadiazine-1,1-dioxides. These are aromatic heterocyclic compounds containing a 1,2,4-benzothiadiazine ring system with two S=O bonds at the 1-position.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

TRPC5 Tchem Short transient receptor potential channel 5 (2 Activities)

Discover Target: TRPC5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Solubilidad: Solvent:DMSO, Max Conc. mg/mL: 45.96, Max Conc. mM: 100

Referencias

1. Hongyang Wang, Bo Zhao, Rui Dong, Ping Wen, Mingjin Fan.  (2024)  Covalent-Organic Framework Nanomaterials: Energy Band Engineering Generating Ultrathin Lubrication Films for Excellent Lubrication.  ACS Applied Materials & Interfaces,      [PMID:39239968] [10.1021/acsami.4c11808]