Butyzamide - ≥99% , CAS No.1110767-45-7

CAS: 1110767-45-7 Cat. No.: B648013 Molecular Weight: 591.55

GRADE & PURITY ≥99%

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

Overview

Butyzamide is an orally active activator of Mpl , a thrombopoietin (TPO) receptor. Butyzamide increases the phosphorylation level of JAK2 , STAT3 , STAT5 and MAPK. Butyzamide increases the level of human platelets in mouse xenotransplantation assay

In Vitro

Butyzamide (3 μM; 15 min) induces the phosphorylation of JAK2, STAT3, STAT5 and MAPK in Ba/F3-hMpl cells. Butyzamide (3 μM; 48 h) induces colony-forming unit-megakaryocyte and polyploid meggakaryocytes from human CD34 + hematopoietic progenitor cellls. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Butyzamide (10 mg/kg, 50 mg/kg; p.o.; once daily for 20 days) increases human platelets in NOG mice transplanted with human fetal liver-derived CD34 + cells . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:JAK2 STAT3 STAT5

Specifications

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

Butyzamide is an orally active activator of Mpl , a thrombopoietin (TPO) receptor. Butyzamide increases the phosphorylation level of JAK2 , STAT3 , STAT5 and MAPK. Butyzamide increases the level of human platelets in mouse xenotransplantation assay.

Storage

Store at 2-8°C, Protected from light, Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ACTIVATOR

Purity

≥99%

Names and Identifiers

• Molecular Weight: 591.55

Chemical and Physical Properties

• Solubility: DMSO : 100 mg/mL (169.05 mM; Need ultrasonic)