C188-9 - Moligand™, 10mM in DMSO , Inhibitor of signal transducer and activator of transcription 3, CAS No.432001-19-9, Inhibitor of signal transducer and activator of transcription 3

CAS: 432001-19-9 Cat. No.: C408822 Molecular Weight: 471.52 EC Number: 836-653-0

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

TTI 101 | Benzenesulfonamide, N-​(1',​2-​dihydroxy[1,​2'-​binaphthalen]​-​4'-​yl)​-​4-​methoxy-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

C188-9 (TTI 101) is a potent inhibitor ofSTAT3that binds to STAT3 with high affinity (KD=4.7±0.4 nM). C188-9 is well tolerated in mice, shows good oral bioavailability, and is concentrated in tumors.
In vitro

C188-9 is a small-molecule inhibitor of Stat3 that targets the phosphotyrosyl peptide binding site within the Stat3 Src homology 2 (SH2) domain with Ki 136 nM. It does not inhibit upstream Jak or Src kinases.

In vivo

Treatment of nude mice bearing xenografts of UM-SCC-17B, a radioresistant HNSCC line, with C188-9, but not C188, prevented tumor xenograft growth. C188-9 was well tolerated in mice, showed good oral bioavailability, and was concentrated in tumors.
Cell Data

cell lines：CD34⁺ cells

Concentrations：0, 0.1, 0.3, 1, 3, 10, 30 μM

Incubation Time：24 h

Powder Purity:≥98%

Specifications

Synonyms

TTI 101 | Benzenesulfonamide, N-​(1', ​2-​dihydroxy[1, ​2'-​binaphthalen]​-​4'-​yl)​-​4-​methoxy-

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

C188-9 (TTI 101) is a potent inhibitor of STAT3 that binds to STAT3 with high affinity (KD=4.7±0.4 nM). C188-9 is well tolerated in mice, shows good oral bioavailability, and is concentrated in tumors.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Inhibitor of signal transducer and activator of transcription 3

Product Properties

• ALogP: 5.152
• hba_count: 3
• HBD Count: 3
• Rotatable Bond: 5

Names and Identifiers

• Isomeric SMILES: COC1=CC=C(C=C1)S(=O)(=O)NC2=CC(=C(C3=CC=CC=C32)O)C4=C(C=CC5=CC=CC=C54)O
• Alternate CAS: 432001-19-9
• MeSH Entry Terms: C188-9 compound;N-(4-hydroxy-3-(2-hydroxynaphthalen-1-yl)naphthalen-1-yl)-4-methoxybenzenesulfonamide;STAT3 inhibitor TTI-101;TTI-101
• Molecular Weight: 471.52
• Reaxy-Rn: 23997464
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=23997464&ln=

Associated Targets(Human)

STAT3 Tchem Signal transducer and activator of transcription 3 (0 Activities)

Discover Target: STAT3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 62 mg/mL (199.69 mM); Ethanol: 62 mg/mL (199.69 mM); Water: Insoluble
• DMSO(mg / mL) Max Solubility: 94
• DMSO(mM) Max Solubility: 199.3552766
• Water(mg / mL) Max Solubility: ＜1