CCT251455 - 10mM in DMSO , CAS No.1400284-80-1

CAS: 1400284-80-1 Cat. No.: C654967 Molecular Weight: 503.98 PubChem CID: 66547425

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

CCT251455 is a potent and selective mitotic kinase monopolar spindle 1 ( MPS1 ) inhibitor with an IC 50 of 3 nM.

In Vitro

CCT251455 is a highly potent inhibitor of MPS1 that demonstrates high selectivity versus kinases tested in a broad kinome profiling panel. CCT251455 inhibits P-MPS1 with an IC 50 of 0.04 μM in cell-based assay and has a GI 50 of 0.16 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CCT251455 demonstrates a good oral pharmacokinetic profile in mouse and rat as well as inhibition of MPS1 activity in vivo following oral administration . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IC50: 3 nM (MPS1)

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

CCT251455 is a potent and selective mitotic kinase monopolar spindle 1 ( MPS1 ) inhibitor with an IC 50 of 3 nM.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Isomeric SMILES: CC(C)(C)OC(=O)N1C(=CC2=CN=C(C=C21)NC3=C(C=C(C=C3)C4=CN=CN4C)Cl)C5=CN(N=C5)C
• PubChem CID: 66547425
• MeSH Entry Terms: CCT251455;tert-butyl 6-(2-chloro-4-(1-methyl-1H-imidazol-5-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo(3,2-c)pyridine-1-carboxylate
• Molecular Weight: 503.98

Associated Targets(Human)

TTK Tchem Dual specificity protein kinase TTK (2 Activities)

Discover Target: TTK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)