≥98% para flujos de trabajo cromatográficos y analíticos sensibles que requieren una interferencia mínima de la línea base.
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Almacenamiento y envío
Store at 2-8°C,Desiccated Envío Wet ice. Consulte el COA específico del lote para conocer las especificaciones exactas.
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Documentos de calidad
SDS, COA, ficha técnica y hoja de especificaciones disponibles para descargar. COA específico del lote accesible mediante búsqueda por número de lote.
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Prueba documental
Citado en 0 publicaciones revisadas por pares sobre cromatografía, síntesis orgánica y reacciones de acoplamiento cruzado.
Descripción general
Censavudine (OBP-601; BMS-986001), a nucleoside analog , is a nucleoside reverse transcriptase inhibitor. Censavudine is a potent HIV inhibitor with EC 50 ranges from 30 nM to 81 nM and 450 nM to 890 nM for HIV-2 and HIV-1 , respectively
In Vitro
BMS-986001 shows greater activity against HIV-2 ROD9 than against HIV-1 NL4-3 ; the mean EC 50 s for BMS-986001 are 74 nM for HIV-2 ROD9 and 890 nM for HIV-1 NL4-3 in the single-cycle assay. HIV-2 ROD9 also showes greater sensitivity to BMS-986001 in 4-day infections of an immortalized T cell line (CEMss), with the mean EC 50 for HIV-2 ROD9 (EC 50 of 0.14 nM) being 30-fold lower than that for HIV-1 NL4-3 (EC 50 of 4.2 nM). BMS-986001 also exhibits full activity against HIV-2 variants whose genomes encoded the single amino acid changes K65R and Q151M in reverse transcriptase. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
The pharmacokinetic parameters of Censavudine (BMS-986001; 100-750 mg/kg) generated from the dried blood spot (DBS) assay and the plasma assay is compared. The ratios of the AUC (0-24 h) and C max for BMS-986001 in DBS compared to those in plasma are consistent at 0.83-0.91 and 0.81-0.97, respectively, across all dose groups in rats. The T max in rat DBS and plasma are also consistent at about 1 h. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Censavudine (OBP-601; BMS-986001), a nucleoside analog , is a nucleoside reverse transcriptase inhibitor. Censavudine is a potent HIV inhibitor with EC 50 ranges from 30 nM to 81 nM and 450 nM to 890 nM for HIV-2 and HIV-1 , respectively.
Condiciones de almacenamiento de almacenamiento
Store at 2-8°C,Desiccated
Enviado en
Wet ice
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
This compound belongs to the class of organic compounds known as nucleoside and nucleotide analogues. These are analogues of nucleosides and nucleotides. These include phosphonated nucleosides, C-glycosylated nucleoside bases, analogues where the sugar unit is a pyranose, and carbocyclic nucleosides, among others.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
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