CFTR corrector 4 - ≥99% , CAS No.1918142-34-3

CAS: 1918142-34-3 Cat. No.: C650763 Molecular Weight: 539.52

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

CFTR corrector 4 (Compound 13), an active (R,R)-form enantiomer, is a highly potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. CFTR corrector 4 can increase CFTR levels at the cell surface and have the potential for treatment of cystic fibrosis

In Vitro

CFTR corrector 4 possesses high potency and efficacy with a EC 50 of 0.028 μM in this HBE-TECC assay that assess the CFTR function, this lead resides in undesirable drug-like space with high molecular weight, and high HPLC Log D, indicating high lipophilicity. HBE-TECC: (Human Bronchial Epithelial-Trans-Epithelial Current Clamp) assay. CFTR corrector 4 is tested its potency and efficacy in human bronchial epithelial (HBE) cells with a EC 50 value 130 nM in the cell surface expression (CSE-HRP) assay. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:EC50:130 nM (CFTR)

Specifications

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

CFTR corrector 4 (Compound 13), an active (R, R)-form enantiomer, is a highly potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. CFTR corrector 4 can increase CFTR levels at the cell surface and have the potentia

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

MODULATOR

Purity

≥99%

Names and Identifiers

• Molecular Weight: 539.52