cGAMP disodium - ≥99% , CAS No.2407516-83-8

CAS: 2407516-83-8 Cat. No.: C649793 Fórmula: C₂₀H₂₂N₁₀Na₂O₁₃P₂ Peso molecular: 718.37

GRADE & PURITY ≥99%

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Descripción general

cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING) , which activates a signaling cascade leading to the production of type I interferons and other immune mediators

In Vitro

cGAMP disodium promotes the antigen-specific proliferation capacity of spleen cells in mice. ?\ncGAMP disodium directly activates murine and human dendritic cells in vitro. ?\nOn stimulation with cGAMP disodium, fibroblasts from the patients showed increased transcription of IFNB1 but not of the genes encoding interleukin-1 (IL1), interleukin-6 (IL6), or tumor necrosis factor (TNF). ?\ncGAMP disodium activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

cGAMP (5 μg; nostril mucosal adjuvant) disodium promotes the antigen-specific cytokine production by spleen cells of immunized mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female C57BL/6 (H-2b) mice 6-8 weeks oldDosage: 5 µg Administration: Nostril mucosal adjuvant Result: Higher titers of ovalbumin (OVA)-specific IgA and total IgG as well as IgG1 and IgG2c in the sera of mice immunized with cGAMP-adjuvanted OVA as compared to sera from OVA-immunized mice.

Form:Solid

IC50& Target:Human Endogenous Metabolite

Specifications

Especificaciones y pureza

≥99%

Mecanismos bioquímicos y fisiológicos

cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING) , which activates a signaling casc

Condiciones de almacenamiento de almacenamiento

Store at -20°C,Desiccated

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

ACTIVATOR

Pureza

≥99%

Nombres e identificadores

Peso molecular

718.37

Propiedades químicas y físicas

• Solubilidad: H2O : 180 mg/mL (250.57 mM; Need ultrasonic and warming)