CGP 42112 TFA - Moligand™, ≥98% , Agonist of AT 2 receptor, CAS No.127060-75-7(free base), Agonist of AT 2 receptor

CAS: 127060-75-7(free base) Cat. No.: C276071 Fórmula: C₅₂H₆₉N₁₃O₁₁(free base) Peso molecular: 1052.19(free base)

CALIDAD & PUREZA Moligand™, ≥98%

Synonyms

AKOS024457173 | N-(3-PYRIDINYLCARBONYL)-L-TYROSYL-N6-(N2-((PHENYLMETHOXY)CARBONYL)-L-ARGINYL)-L-LYSYL-L-HISTIDYL-L-PROLYL-L-ISOLEUCINE | UNII-9Q3V7W3XDD | (2S,3S)-2-[[(2S)-1-[(2S)-2-[[(2S)-6-[[(2S)-5-(diaminomethylideneamino)-2-(phenylmethoxycarbonylamino

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Descripción general

CGP-42112 TFA is A potent angiotensin receptor AT2 agonist that inhibits the increase in the activity of LPS-produced protein kinase A

Especificaciones

Sinónimos

AKOS024457173 | N-(3-PYRIDINYLCARBONYL)-L-TYROSYL-N6-(N2-((PHENYLMETHOXY)CARBONYL)-L-ARGINYL)-L-LYSYL-L-HISTIDYL-L-PROLYL-L-ISOLEUCINE | UNII-9Q3V7W3XDD | (2S,3S)-2-[[(2S)-1-[(2S)-2-[[(2S)-6-[[(2S)-5-(diaminomethylideneamino)-2-(phenylmethoxycarbonylamino

Especificaciones y pureza

Moligand™, ≥98%

Mecanismos bioquímicos y fisiológicos

Potent, selective AT 2 receptor ligand (K i = 0.24 nM). Shows agonist effects at proximal tubule AT 2 receptors. Inhibits Na + , K + -ATPase. Inhibits Angiotensin-II induced aortic contraction (IC 50 = 1.9 μM). Induces sodium excretion in vivo.

Aplicación

CGP-42112A has been used: in the isolation of RNA from fibroblast-like synoviocytes from rheumatoid arthritis patients (RA-FLS)； to study its effects on the ERK2 phosphorylation in the cardiomyoblast cell line； as a stimulator of angiotensin II type 2 (AT

Condiciones de almacenamiento de almacenamiento

Store at -20°C,Desiccated

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

AGONIST

Mecanismo de acción

Agonist of AT 2 receptor

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureza

≥98%

Nombres e identificadores

Peso molecular

1052.19(free base)

Objetivos asociados (humanos)

AGTR2 Tchem Type-2 angiotensin II receptor (0 Activities)

Discover Target: AGTR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Solubilidad: Soluble in water

Preguntas frecuentes

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 127060-75-7(free base), the molecular formula is C52H69N13O11(free base), and the molecular weight is 1052.19(free base) g/mol.

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.