Ciclopirox - Moligand™, 10mM in DMSO , Aluminium chelating agent, CAS No.29342-05-0, Aluminium chelating agent

CAS: 29342-05-0 Cat. No.: C408974 Molecular Weight: 207.27 EC Number: 249-577-2

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

6-​cyclohexyl-​1-​hydroxy-​4-​methyl-2(1H)​-​pyridinone

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Ciclopirox Ciclopirox is a broad-spectrum antifungal agent working as an iron chelator .
In vitro

Ciclopirox olamine (CPX) is a lipophilic bidentate iron chelator that stabilizes HIF-1alpha under normoxic conditions at lower concentrations than other iron chelators, probably by inhibiting HIF-1alpha hydroxylation. Ciclopirox olamine (CPX)-induced HIF-1 mediates reporter gene activity and endogenous HIF-1 target gene expression, including elevation of transcription, mRNA, and protein levels of the vascular endothelial growth factor (VEGF). Ciclopirox inhibits growth of C. albicans yeast and hyphal cells in a dose-dependent manner. Ciclopirox blocks H2O2-induced mitochondrial injury by maintaining mitochondrial transmembrane potential (Deltapsim). Ciclopirox completely blocks H2O2-stimulated release of lactate dehydrogenase (a marker of cell death) and decreases in MTT reduction (a marker of mitochondrial function) in adenocarcinoma SK-HEP-1 cells. Ciclopirox effectively inhibits H2O2-induced mitochondrial permeability transition pore (MPTP) opening. Ciclopirox increases the MTP, maintained it high, and blocks the ATP depletion in glucose-deprived SIN-1-treated astrocytes. Ciclopirox protects astrocytes from peroxynitritecytotoxicity by attenuating peroxynitrite-induced mitochondrial dysfunction. Ciclopirox is a substituted pyridone antimycotic drug, unrelated to the imidazole derivatives and its topical application ensures maximum local bioavailability. Ciclopirox acts on fungi by inhibiting the intracellular uptake of essential substrates and ions and this probably acts on the Candida ability to express its adherence mechanisms.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

6-​cyclohexyl-​1-​hydroxy-​4-​methyl-2(1H)​-​pyridinone

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Ciclopirox is a broad-spectrum antifungal agent working as an iron chelator.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

CHELATING AGENT, INHIBITOR

Mechanism of action

Aluminium chelating agent

Product Properties

• ALogP: 2

Names and Identifiers

• Isomeric SMILES: CC1=CC(=O)N(C(=C1)C2CCCCC2)O
• Molecular Weight: 207.27
• Reaxy-Rn: 1533423
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1533423&ln=

Associated Targets(Human)

PARP1 Tclin Poly [ADP-ribose] polymerase 1 (0 Activities)

Discover Target: PARP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 2 mg/mL (3.09 mM); Water: Insoluble; Ethanol: Insoluble