Cortisone acetate - 10mM in DMSO , Glucocorticoid receptor agonist, CAS No.50-04-4, Glucocorticoid receptor agonist

CAS: 50-04-4 Cat. No.: C408661 Molecular Weight: 402.48 EC Number: 200-006-5

GRADE & PURITY 10mM in DMSO

Synonyms

NSC 49420 | 2-((8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Cortisone acetate Cortisone acetate (Cortone, NSC 49420) is an acetate salt form of cortisone that is a steroid hormone and a glucocorticoid.
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

NSC 49420 | 2-((8S, 9S, 10R, 13S, 14S, 17R)-17-hydroxy-10, 13-dimethyl-3, 11-dioxo-2, 3, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Cortisone acetate (Cortone, NSC 49420) is an acetate salt form of cortisone that is a steroid hormone and a glucocorticoid.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

AGONIST

Mechanism of action

Glucocorticoid receptor agonist

Product Properties

• ALogP: 2.1

Names and Identifiers

• Isomeric SMILES: CC(=O)OCC(=O)[C@]1(CC[C@@H]2[C@@]1(CC(=O)[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C)O
• Molecular Weight: 402.48
• Reaxy-Rn: 1897065
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1897065&ln=

Chemical and Physical Properties

• Melt Point(°C): 237-240 °C

References

1. Lingna Xu, Ren-ai Xu, Dan Zhang, Shanshan Su, Hanyan Xu, Qing Wu, Yuping Li.  (2023)  The changes of expressive levels of IL-17A, STAT3 and RORγt in different invasive pulmonary aspergillosis mice.  Infection and Drug Resistance,      [PMID:30214252] [10.2147/IDR.S172949]

2. Yangjie LI, Jiaying HUANG, Jihui FANG, Zhiye HUANG.  (2022)  [Fast screening and confirmation of 73 common prohibited compounds in cosmetics by ultra performance liquid chromatography-quadrupole-time-of-flight high resolution mass spectrometry]..  Chinese Journal of Chromatography,  40  (5): (433-442).  [PMID:35478002] [10.3724/sp.j.1123.2021.09010]

3. Yuan Huang, Zhiqun Zheng, Liying Huang, Hong Yao, Xiao shan Wu, Shaoguang Li, Dandan Lin.  (2017)  Optimization of dispersive liquid-phase microextraction based on solidified floating organic drop combined with high-performance liquid chromatography for the analysis of glucocorticoid residues in food.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:28259095] [10.1016/j.jpba.2017.02.026]

4. Qiyue Zhang, Guanglin Li, Yanmei Wang, Chen Yang, Wenhui Bai, Qingqing Li, Jiye Zhang, Peipei Zhang.  (2025)  Cas5 Regulates the Exposure of β-Glucan, the Cell Surface Hydrophobicity, and the Expression of Cell Wall Proteins to Remodel the Candida albicans Cell Wall and Participates in the Recruitment of Neutrophils.  Microorganisms,  13  (3): (683).  [PMID:40142575] [10.3390/microorganisms13030683]