CP-10 is a PROTAC connected by ligands for Cereblon and CDK , with highly selective, specific, and remarkable CDK6 degradation ( DC 50 =2.1 nM). It inhibits proliferation of several haematopoietic cancer cells with impressive potency including multiple myeloma, and can still degrades mutated and overexpressed CDK6
In Vitro
CP-10 induces nearly 72% degradation of CDK6 at 10 nM and 89% at 100 nM in human glioblastoma U251 cells. The degradation of CDK4 induced by CP-10 is far weaker than that of CDK6 (DC 50 : 50-80 fold). ?\nCP-10 displays a cell inhibition potential in multiple myeloma cell MM.1S (IC 50 ≈10 nM) and mantle cell lymphoma cells (in Mino, IC 50 ≈8 nM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:CDK6 2.1 nM (DC 50 ) Cereblon
Especificaciones
Especificaciones y pureza
≥98%
Mecanismos bioquímicos y fisiológicos
CP-10 is a PROTAC connected by ligands for Cereblon and CDK , with highly selective, specific, and remarkable CDK6 degradation ( DC 50 =2.1 nM). It inhibits proliferation of several haematopoietic cancer cells with impressive potency including multiple my
Condiciones de almacenamiento de almacenamiento
Store at -20°C,Argon charged
Enviado en
Ice chest + Ice pads
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
This compound belongs to the class of organic compounds known as pyridinylpiperazines. These are compounds containing a pyridinylpiperazine skeleton, which consists of a pyridine linked (not fused) to a piperazine by a bond by a single bond that is not part of a ring.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Propiedades químicas y físicas
Solubilidad
DMSO : 200 mg/mL (229.37 mM; Need ultrasonic)
Calculadoras de soluciones
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Reseñas
Reseñas de cliente
Preguntas frecuentes
What is the purity of this product?
This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.
How should this product be stored?
Store at ?20 °C under argon. It is supplied under an argon blanket; reseal under inert gas after each use.
How is this product shipped?
This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 2366268-80-4, the molecular formula is C44H49N13O7, and the molecular weight is 871.94 g/mol. InChIKey PACRWHUPEPCFHX-UHFFFAOYSA-N.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.
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