CRANAD-2 - ≥95% , CAS No.1193447-34-5

CAS: 1193447-34-5 Cat. No.: C276131 Molecular Weight: 410.26 EC Number: 806-116-5

GRADE & PURITY ≥95%

Synonyms

CRANAD 2 | BDBM50598536 | 4,4'-((1E,1'E)-(2,2-difluoro-2H-1l3,3,2l4-dioxaborinine-4,6-diyl)bis(ethene-2,1-diyl))bis(N,N-dimethylaniline) | AKOS024458354 | CRANAD-2 | EX-A4805 | 1193447-34-5 | [4-[(2Z)-2-[6-[(E)-2-[4-(dimethylamino)phenyl]ethenyl]-2,2-difl

Storage

Protected from light,Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Overview

Shipped at 4°C. Store at -20°C. Store In the Dark. Store under desiccating conditions.

Specifications

Synonyms

CRANAD 2 | BDBM50598536 | 4, 4'-((1E, 1'E)-(2, 2-difluoro-2H-1l3, 3, 2l4-dioxaborinine-4, 6-diyl)bis(ethene-2, 1-diyl))bis(N, N-dimethylaniline) | AKOS024458354 | CRANAD-2 | EX-A4805 | 1193447-34-5 | [4-[(2Z)-2-[6-[(E)-2-[4-(dimethylamino)phenyl]ethenyl]-2, 2-difl

Specifications & Purity

≥95%

Biochemical and Physiological Mechanisms

Near-infrared (NIR) Amyloid-β fluorescent probe. Upon interacting with Amyloid-β aggregates displays a 70-fold increase in fluorescence intensity accompanied by a 90 nm blue shift from 805 to 715 nm. Demonstrates high affinity for amyloid-β aggregates

Storage

Protected from light, Store at -20°C, Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥95%

Names and Identifiers

• Pubchem Sid: 504772612
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504772612
• Canonical Smiles: [B-]1(OC(=CC(=CC=C2C=CC(=[N+](C)C)C=C2)O1)C=CC3=CC=C(C=C3)N(C)C)(F)F
• IUPAC Name: [4-[(2Z)-2-[6-[(E)-2-[4-(dimethylamino)phenyl]ethenyl]-2,2-difluoro-1,3-dioxa-2-boranuidacyclohex-5-en-4-ylidene]ethylidene]cyclohexa-2,5-dien-1-ylidene]-dimethylazanium
• InChIKey: PVXQJYXODFZTBR-UHFFFAOYSA-N
• INCHI: 1S/C23H25BF2N2O2/c1-27(2)20-11-5-18(6-12-20)9-15-22-17-23(30-24(25,26)29-22)16-10-19-7-13-21(14-8-19)28(3)4/h5-17H,1-4H3
• Isomeric SMILES: [B-]1(OC(=C/C(=C/C=C2C=CC(=[N+](C)C)C=C2)/O1)/C=C/C3=CC=C(C=C3)N(C)C)(F)F
• Molecular Weight: 410.26
• Reaxy-Rn: 19805444
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=19805444&ln=

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Soluble in DMSO to 5 mM (with warming)
• Sensitivity: Moisture and lightsensitive