CXCR2-IN-1 - 10mM in DMSO , CAS No.1873376-49-8

CAS: 1873376-49-8 Cat. No.: C654822 Fórmula: C₁₉H₂₀Cl₂FN₃O₄S Peso molecular: 476.35 PubChem CID: 127020968

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

CXCR2-IN-1 is a central nervous system penetrant CXCR2 antagonist with a pIC 50 of 9.3.

In Vitro

CXCR2 plays an important role in the activation and recruitment of neutrophils to sites of inflammation. CXCR2-IN-1 (compound 22) shows favorable central nervous system penetration property (Br/Bl>0.45). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CXCR2-IN-1 shows efficacy in a cuprizone-induced demyelination model through oral administration, providing evidence to support CXCR2 to be a potential therapeutic target to treat demyelinating diseases such as multiple sclerosis . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:CXCR2 9.3 (pIC 50 )

Specifications

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

CXCR2-IN-1 is a central nervous system penetrant CXCR2 antagonist with a pIC 50 of 9.3.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Tipo de acción

INHIBITOR

Nombres e identificadores

Isómeros SMILES

CN1CCC(CC1)S(=O)(=O)C2=C(C=CC(=C2O)NC(=O)NC3=C(C(=CC=C3)F)Cl)Cl

PubChem CID

127020968

Peso molecular

476.35

Objetivos asociados (humanos)

CXCR2 Tchem C-X-C chemokine receptor type 2 (2 Activities)

Discover Target: CXCR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)