Cytisine - Moligand™, 10mM in DMSO , Neuronal acetylcholine receptor; alpha4/beta2 partial agonist, CAS No.485-35-8, Neuronal acetylcholine receptor; alpha4/beta2 partial agonist

CAS: 485-35-8 Cat. No.: C408449 Molecular Weight: 190.24 EC Number: 207-616-0

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Baphitoxine,Sophorine | 1,5-Methano-8H-pyrido[1,2-a][1,5]diazocin-8-one, 1,2,3,4,5,6-hexahydro-, (1R,5S)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Cytisine (Baphitoxine, Sophorine) is a nicotinic acetylcholine receptor agonist.
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

Baphitoxine, Sophorine | 1, 5-Methano-8H-pyrido[1, 2-a][1, 5]diazocin-8-one, 1, 2, 3, 4, 5, 6-hexahydro-, (1R, 5S)-

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Cytisine (Baphitoxine, Sophorine) is a nicotinic acetylcholine receptor agonist.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

PARTIAL AGONIST

Mechanism of action

Neuronal acetylcholine receptor; alpha4/beta2 partial agonist

Product Properties

• ALogP: 0.2

Names and Identifiers

• Isomeric SMILES: C1[C@H]2CNC[C@@H]1C3=CC=CC(=O)N3C2
• WGK Germany: 3
• RTECS: HA4025000
• UN Number: 2811
• Molecular Weight: 190.24
• Reaxy-Rn: 156877
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=156877&ln=

Associated Targets(Human)

CHRNA7 Tchem Neuronal acetylcholine receptor subunit alpha-7 (3 Activities)

Discover Target: CHRNA7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 59 mg/mL (198.96 mM); Ethanol: 59 mg/mL (198.96 mM); Water: Insoluble
• Specific Rotation[α]: -112° (C=1,EtOH)
• Boil Point(°C): 218°C
• Melt Point(°C): 155°C

References

1. Zhang Chunhua, Wu Huiqin, Huang Xiaolan, Zhu Zhixin, Luo Huitai, Huang Fang, Lin Xiaoshan.  (2012)  Simultaneous Determination of Toxic Alkaloids in Blood and Urine by HPLC–ESI–MS/MS.  CHROMATOGRAPHIA,  75  (9): (499-511).  [PMID:] [10.1007/s10337-012-2216-6]