Daphnetin - 10mM in DMSO , CAS No.486-35-1

CAS: 486-35-1 Cat. No.: D408432 Fórmula: C₉H₆O₄ Peso molecular: 178.14 Beilstein Registry Number: 18(5)3,211 Número EC: 207-632-8

CALIDAD & PUREZA 10mM in DMSO

Synonyms

7,​8-​dihydroxy-2H-​1-​benzopyran-​2-​one

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Daphnetin, a natural coumarin derivative, is a protein kinase inhibitor, inhibitsEGFR,PKAand PKC withIC50of 7.67 μM, 9.33 μM and 25.01 μM, respectively, also known to exhibit anti-inflammatory and anti-oxidant activities.
In vitro

Daphnetin strongly inhibits not only EGF receptor-catalyzed tyrosine phosphorylation of exogenous substrate but also PKA and PKC activities. Daphnetin inhibits MCF-7 estrogen-responsive human carcinoma cell line at 24-hour exposure with IC50 of 73 μM. Daphnetin reduces the level of cyclin D1 even at 50 μM. Daphnetin protects the cortical neurons against dexamethasone-induced reduction of cell viability in a dose-dependent manner. Daphnetin inhibits the activities of endogenous or recombinant TaPRK in a specific and dose-dependent manner. daphnetin causes a 50% inhibition (IC50) of 3H-hypoxanthine incorporation by Plasmodium falciparum at concentrations between 25 μM and 40 μM. Daphnetin inhibits the mitogenic signalling of ERK1/ERK2.

In vivo

Daphnetin at 140 mg/kg significantly decreases uterine weights by 39.5%. Two and 8 mg/kg administration of Daphnetin could improve the performance of stress mice in Morris water maze tests and forced swimming tests. Daphnetin significantly prolongs survival of P. yoelli-infected mice.
Cell Data

cell lines：

Concentrations：12.5 μM, 25 μM, 50 μM, 100 μM, 200 μM

Incubation Time：24 hours, 48 hours, and 72 hours

Powder Purity:≥99%

Especificaciones

Sinónimos

7,​8-​dihydroxy-2H-​1-​benzopyran-​2-​one

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Daphnetin, a natural coumarin derivative, is a protein kinase inhibitor, inhibits EGFR, PKA and PKC with IC50 of 7.67 μM, 9.33 μM and 25.01 μM, respectively, also known to exhibit anti-inflammatory and anti-oxidant activities.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Nombres e identificadores

Isómeros SMILES

C1=CC(=C(C2=C1C=CC(=O)O2)O)O

RTECS

GN6382600

Peso molecular

178.14

Beilstein

18(5)3,211

Reaxy-Rn

9372

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9372&ln=

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 52 mg/mL (201.37 mM); Ethanol: 52 mg/mL (201.37 mM); Water: Insoluble
• Punto de fusión (°C): 256°C

Preguntas frecuentes

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 486-35-1, the molecular formula is C9H6O4, and the molecular weight is 178.14 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.