Deferoxamine - Moligand™, ≥98% , CAS No.70-51-9

CAS: 70-51-9 Cat. No.: D651377 Fórmula: C₂₅H₄₈N₆O₈ Peso molecular: 560.68 Número EC: 200-738-5

CALIDAD & PUREZA Moligand™, ≥98%

Synonyms

Deferoxamine B | Deferriferrioxamine B; Deferrioxamine | N1-(5-Aminopentyl)-N1-hydroxy-N4-(5-(N-hydroxy-4-((5-(N-hydroxyacetamido)pentyl)amino)-4-oxobutanamido)pentyl)succinamide

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

Deferoxamine (Deferoxamine B) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine upregulates HIF-1α levels with good antioxidant activity. Deferoxamine also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19.

Especificaciones

Sinónimos

Deferoxamine B | Deferriferrioxamine B; Deferrioxamine | N1-(5-Aminopentyl)-N1-hydroxy-N4-(5-(N-hydroxy-4-((5-(N-hydroxyacetamido)pentyl)amino)-4-oxobutanamido)pentyl)succinamide

Especificaciones y pureza

Moligand™, ≥98%

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Pureza

≥98%

Nombres e identificadores

Pubchem Sid

528764269

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/528764269

Sonrisas canónicas

CC(=O)N(CCCCCNC(=O)CCC(=O)N(CCCCCNC(=O)CCC(=O)N(CCCCCN)O)O)O

IUPAC Name

N-[5-[[4-[5-[acetyl(hydroxy)amino]pentylamino]-4-oxobutanoyl]-hydroxyamino]pentyl]-N'-(5-aminopentyl)-N'-hydroxybutanediamide

InChIKey

UBQYURCVBFRUQT-UHFFFAOYSA-N

INCHI

1S/C25H48N6O8/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34)

Isómeros SMILES

CC(=O)N(CCCCCNC(=O)CCC(=O)N(CCCCCNC(=O)CCC(=O)N(CCCCCN)O)O)O

Peso molecular

560.68

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Clase Carboxylic acids and derivatives
      • Subclass Carboxylic acid derivatives
        • Level5 Carboxylic acid amides
          • Level6 Primary carboxylic acid amides
            • Level7 Hydroxamic acids
              • Level8 Acetohydroxamic acids

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Clase: Carboxylic acids and derivatives
• Subclass: Carboxylic acid derivatives
• Intermediate Tree Nodes: Carboxylic acid amides - Primary carboxylic acid amides - Hydroxamic acids
• Direct Parent: Acetohydroxamic acids
• Alternative Parents: Acetamides Amino acids and derivatives Propargyl-type 1,3-dipolar organic compounds Carboximidic acids Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Acetamide - Acetohydroxamic acid - Amino acid or derivatives - Carboximidic acid - Carboximidic acid derivative - Propargyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Carbonyl group - Organic nitrogen compound - Primary amine - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Amine - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Organic oxide - Aliphatic acyclic compound
• Descripción: This compound belongs to the class of organic compounds known as acetohydroxamic acids. These are organic compounds that contain a hydroxamic acid group carrying a methyl group attached to its carbon center.
• External Descriptors: a hydroxamate siderophore

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

CA2 Tclin Carbonic anhydrase II (17698 Activities)

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TOP2A Tclin DNA topoisomerase II alpha (6317 Activities)

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TYR Tclin Tyrosinase (717 Activities)

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TF Tbio Serotransferrin (88 Activities)

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HDAC2 Tclin Histone deacetylase 2 (3971 Activities)

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CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

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MMP12 Tchem Matrix metalloproteinase 12 (1130 Activities)

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CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

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CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

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Homo sapiens (32628 Activities)

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DLD-1 (17511 Activities)

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HL-60 (67320 Activities)

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HT-29 (80576 Activities)

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K562 (73714 Activities)

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MCF7 (126967 Activities)

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MRC5 (9203 Activities)

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NHDF (1164 Activities)

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PC-3 (62116 Activities)

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Raji (5516 Activities)

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SH-SY5Y (11521 Activities)

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SK-N-MC (815 Activities)

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SK-OV-3 (52876 Activities)

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SW480 (6023 Activities)

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A549 (127892 Activities)

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HCT-116 (91556 Activities)

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HepG2 (196354 Activities)

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A2780 (11979 Activities)

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SF-268 (49410 Activities)

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KB (17409 Activities)

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HeLa (62764 Activities)

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MDA-MB-231 (73002 Activities)

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HCT-15 (51914 Activities)

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HIF1A Tchem Hypoxia-inducible factor 1 alpha (6027 Activities)

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SMMC-7721 (5516 Activities)

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GNAS Tbio Guanine nucleotide-binding protein G(s), subunit alpha (103405 Activities)

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POLI Tchem DNA polymerase iota (116820 Activities)

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KDM4A Tchem Lysine-specific demethylase 4A (52245 Activities)

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

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DMS-53 (76 Activities)

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GMNN Tbio Geminin (128009 Activities)

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IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 Activities)

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CHP-126 (79 Activities)

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L02 (4864 Activities)

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SK-N-BE(2)-M17 (195 Activities)

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Objetivos asociados (no humanos)

Trypsin (394 Activities)

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Mmp2 Matrix metalloproteinase-2 (12 Activities)

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Hdac6 Histone deacetylase 6 (222 Activities)

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Pseudomonas aeruginosa (123386 Activities)

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Escherichia coli (133304 Activities)

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Chlamydia trachomatis (699 Activities)

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Mycobacterium avium (4587 Activities)

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Mycobacterium avium subsp. paratuberculosis (238 Activities)

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Leishmania infantum (5912 Activities)

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Trypanosoma brucei (78846 Activities)

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Plasmodium falciparum (966862 Activities)

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Plasmodium yoelii (6656 Activities)

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Mus musculus (284745 Activities)

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Rattus norvegicus (775804 Activities)

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Human immunodeficiency virus 1 (70413 Activities)

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Monkey (844 Activities)

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MDCK (10148 Activities)

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NIH3T3 (5395 Activities)

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Sapajus apella (176 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Brain (1 Activities)

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Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

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Deoxyhypusine hydroxylase (6 Activities)

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SARS-CoV-2 (38078 Activities)

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Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: DMSO : 12.5 mg/mL (22.29 mM; ultrasonic and warming and heat to 60°C)
• Peso molecular: 560.700 g/mol
• XLogP3: -2.100
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 23
• Exact Mass: 560.353 Da
• Monoisotopic Mass: 560.353 Da
• Topological Polar Surface Area: 206.000 Ų
• Heavy Atom Count: 39
• Formal Charge: 0
• Complexity: 739.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Preguntas frecuentes

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 70-51-9, the molecular formula is C25H48N6O8, and the molecular weight is 560.68 g/mol. InChIKey UBQYURCVBFRUQT-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.