Deltarasin hydrochloride - 10mM in DMSO , CAS No.1613404-76-4

CAS: 1613404-76-4 Cat. No.: D655480 Fórmula: C₄₀H₃₈ClN₅O Peso molecular: 640.22 PubChem CID: 78357804

CALIDAD & PUREZA 10mM in DMSO

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Deltarasin hydrochloride is an inhibitor of KRAS-PDEδ interaction with K d of 38 nM for binding to purified PDEδ.

In Vitro

In liver cells, deltarasin inhibits the interaction of RAS with PDEδ with K D of 41 nM. Inhibition of PDEδ-KRAS interaction by deltarasin suppresses proliferation of human pancreatic ductal adenocarcinoma cells that are dependent on oncogenic KRAS. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Deltarasin (10 mg/kg, i.p.) impairs dose-dependent tumor growth in nude mice bearing subcutaneous human Panc-Tu-I tumour cell xenografts . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Kd: 38 nM (PDEδ)

Especificaciones

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Deltarasin hydrochloride is an inhibitor of KRAS-PDEδ interaction with K d of 38 nM for binding to purified PDEδ.

Condiciones de almacenamiento de almacenamiento

Desiccated,Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Tipo de acción

INHIBITOR

Nombres e identificadores

Isómeros SMILES

C1CNCCC1[C@@H](COC2=CC=C(C=C2)C3=NC4=CC=CC=C4N3CC5=CC=CC=C5)N6C7=CC=CC=C7N=C6C8=CC=CC=C8.Cl

CAS alternativo

1440898-82-7

PubChem CID

78357804

Peso molecular

640.22