DHODH-IN-23 - ≥99% , CAS No.1346705-53-0

CAS: 1346705-53-0 Cat. No.: D651444 Fórmula: C₂₄H₂₁ClFNO₄ Peso molecular: 441.88

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

DHODH-IN-23 (Compound A) is an orally active DHODH inhibitor that can be used for the research of cancer.

In Vitro

DHODH-IN-23 (Compound A; 72 h) inhibits acute myeloid leukemia cells proliferation. DHODH-IN-23 (0.1-3 μM; 72 h) induces CDllb expression in THP-1 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: U937, HL-60, THP-1, KG-1 and MV411 Concentration: Incubation Time: 72 h Result: Inhibited cell growth with GI 50 s of 2.4, 2.5, 2.5, 3.5 and 7.6 μM against U937, THP-1, MV411 HL-60 and KG-1, respectively. RT-PCRCell Line: THP-1 cells Concentration: 72 h Incubation Time: 0.1, 1 and 3 μM Result: Induced CDllb mRNA expression.

In Vivo

DHODH-IN-23 (Compound A; 30 mg/kg; oral; twice daily for 21 days) shows antitumor activity in MV411 mouse xenograft model . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: MV411 mouse xenograft model Dosage: 30 mg/kg Administration: Oral administration, twice daily for 21 days Result: Demonstrated significant anti-tumor activity both as a single agent and in combination with Cytarabine at 20 mg/kg with tumor growth inhibitions of 37 and 73% respectively.

Form:Solid

Specifications

Especificaciones y pureza

≥99%

Mecanismos bioquímicos y fisiológicos

DHODH-IN-23 (Compound A) is an orally active DHODH inhibitor that can be used for the research of cancer.

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Pureza

≥99%

Nombres e identificadores

Peso molecular

441.88

Propiedades químicas y físicas

• Solubilidad: DMSO : 125 mg/mL (282.88 mM; Need ultrasonic)

Preguntas frecuentes

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1346705-53-0, the molecular formula is C24H21ClFNO4, and the molecular weight is 441.88 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.