Dyclonine HCl - 10mM in DMSO , Sodium channel alpha subunit blocker, CAS No.536-43-6, Sodium channel alpha subunit blocker

CAS: 536-43-6 Cat. No.: D409239 Molecular Weight: 325.87 EC Number: 208-633-6

GRADE & PURITY 10mM in DMSO

Synonyms

1-​(4-​butoxyphenyl)​-​3-​(1-​piperidinyl)​-1-​propanone,hydrochloride (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Dyclonine HCl Dyclonine HCl is a hydrochloride salt form of dyclonine which is an oral anaesthetic, reversibly binds to activated sodium channels on the neuronal membrane, thereby decreasing the neuronal membrane's permeability to sodium ions, leading t
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

1-​(4-​butoxyphenyl)​-​3-​(1-​piperidinyl)​-1-​propanone, hydrochloride (1:1)

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Dyclonine HCl is a hydrochloride salt form of dyclonine which is an oral anaesthetic, reversibly binds to activated sodium channels on the neuronal membrane, thereby decreasing the neuronal membrane\'s permeability to sodium ions, leading to an increased

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

BLOCKER

Mechanism of action

Sodium channel alpha subunit blocker

Names and Identifiers

• Isomeric SMILES: CCCCOC1=CC=C(C=C1)C(=O)CCN2CCCCC2.Cl
• WGK Germany: 3
• RTECS: UG8750000
• Molecular Weight: 325.87
• Reaxy-Rn: 3744808
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3744808&ln=

Chemical and Physical Properties

• Melt Point(°C): 175-176°C

References

1. Xiaokang Guan, Qiao Lu, Xiangxu Zhao, Xiaowen Yan, Renato Zenobi.  (2023)  Spatio-Temporal Analysis of Anesthetics in Mice by Solid-Phase Microextraction: Dielectric Barrier Discharge Ionization Mass Spectrometry.  ANALYTICAL CHEMISTRY,      [PMID:37560898] [10.1021/acs.analchem.3c02123]

2. Wen-Jing Li, Li-Ying Wen, Yu-Sang Li, He-Bin Tang.  (2026)  Topical Application of Frankincense Oil Extract Potently Ameliorates Psoriasis-like Dermatitis in Mice via Anti-Inflammatory and Skin Barrier-Protective Effects.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  27  (6):   [PMID:] [10.3390/ijms27062629]