Dynasore - 10mM in DMSO , CAS No.304448-55-3

CAS: 304448-55-3 Cat. No.: D423149 Molecular Weight: 322.31
AVAILABLE TO ORDER
GRADE & PURITY 10mM in DMSO
Synonyms
Dynasore;3-Hydroxy-2-naphthalenecarboxylic acid [(3,4-dihydroxyphenyl)methylene]hydrazide
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
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Size
Status
Price
Qty
1ml
D423149-1ml
1
$217.90
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Why this grade

10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 12 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Dynasore is a cell-permeable, reversible non-competitive dynamin inhibitor of GTPase activity of dynamin 1/2, with IC50 of 15 μM, also inhibits the mitochondrial dynamin Drp1, with no effect against other small GTPase
An inhibitor of Dynamin I and Dynamin II

Specifications

Synonyms
Dynasore;3-Hydroxy-2-naphthalenecarboxylic acid [(3, 4-dihydroxyphenyl)methylene]hydrazide
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
Dynasore is a non-competitive, cell-permeable semicarbazone compound inhibitor of Dynamin I and Dynamin II. Members of the Dynamin family, including Dynamin I, Dynamin II and Dynamin III, are GTPase, microtubule-associated proteins which are involved in e
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Names and Identifiers
Isomeric SMILES C1=CC=C2C=C(C(=CC2=C1)C(=O)N/N=C/C3=CC(=C(C=C3)O)O)O
Molecular Weight 322.31
Reaxy-Rn 20640593
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=20640593&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
SensitivityHeat Sensitive
Documents & Articles
Citations of This Product
References
1. Dan Yuan, Qi Li, Qibo Zhang, Feibai Zhou, Qiangzhong Zhao, Mouming Zhao.  (2023)  Enhanced curcumin transportation across epithelial barrier by mucus-permeable soy protein nanoparticles-mediated dual transcytosis pathways.  FOOD CHEMISTRY,      [PMID:37897825] [10.1016/j.foodchem.2023.137771]
2. Siyuan Huang, Qi Su, Xiaoqiang Hou, Kuankuan Han, Shufang Ma, Bingshe Xu, Yingjun Yang.  (2022)  Influence of Colonies’ Morphological Cues on Cellular Uptake Capacity of Nanoparticles.  Frontiers in Bioengineering and Biotechnology,      [PMID:35711638] [10.3389/fbioe.2022.922159]
3. Wang Huawei, Shan Xiajing, Ren Mengtian, Shang Mengdi, Zhou Chuanzheng.  (2021)  Nucleosomes enter cells by clathrin- and caveolin-dependent endocytosis.  NUCLEIC ACIDS RESEARCH,  49  (21): (12306-12319).  [PMID:34865123] [10.1093/nar/gkab1121]
4. Zhuqing Dai, Jiangfeng Song, Ye Chen, Lei Feng, Yayuan Xu, Dajing Li, Caie Wu, Zhongyuan Zhang, Jun Liu.  (2021)  Study on the bioavailability of stevioside-encapsulized lutein and its mechanism.  FOOD CHEMISTRY,      [PMID:33756320] [10.1016/j.foodchem.2021.129528]
5. Gao Feng, Shao Tianyi, Yu Yunpeng, Xiong Yujie, Yang Lihua.  (2021)  Surface-bound reactive oxygen species generating nanozymes for selective antibacterial action.  Nature Communications,  12  (1): (1-18).  [PMID:33531505] [10.1038/s41467-021-20965-3]
6. Le Feng, Xiao Xiao, Jing Liu, Junyan Wang, Nan Zhang, Tao Bing, Xiangjun Liu, Ziping Zhang, Dihua Shangguan.  (2020)  Immunomodulatory Effects of Lycium barbarum Polysaccharide Extract and Its Uptake Behaviors at the Cellular Level.  MOLECULES,  25  (6): (1351).  [PMID:32188121] [10.3390/molecules25061351]
7. Shanshan Wang, Zhangkun Liu, Yuxiu Zou, Xiaofang Lai, Ding Ding, Long Chen, Liqin Zhang, Yuan Wu, Zhuo Chen, Weihong Tan.  (2016)  Elucidating the cellular uptake mechanism of aptamer-functionalized graphene-isolated-Au-nanocrystals with dual-modal imaging.  ANALYST,  141  (11): (3337-3342).  [PMID:27111129] [10.1039/C6AN00483K]
8. Liu Di, Guo Hua, Zheng Wenyun, Zhang Na, Wang Tianwen, Wang Ping, Ma Xingyuan.  (2016)  Discovery of the cell-penetrating function of A2 domain derived from LTA subunit of Escherichia coli heat-labile enterotoxin.  APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,  100  (11): (5079-5088).  [PMID:26960316] [10.1007/s00253-016-7423-x]
9. Jiabin Zhang, Xiaodie Chen, Yurong Chai, Yuanyuan Jin, Fenfang Li, Chenya Zhuo, Yanteng Xu, Haixia Wang, Enguo Ju, Yeh-Hsing Lao, Xi Xie, Mingqiang Li, Yu Tao.  (2025)  Mesenchymal stromal/stem cell spheroid-derived extracellular vesicles advance the therapeutic efficacy of 3D-printed vascularized artificial liver lobules in liver failure treatment.  Bioactive Materials,      [PMID:40124595] [10.1016/j.bioactmat.2025.02.042]
10. Min Mu, Hui Li, Susu Xiao, Chenqian Feng, Bo Chen, Rangrang Fan, Nianyong Chen, Gang Guo.  (2025)  Spatiotemporal-Controlled Nanoagonists Triggered STING Activation for Cascade-Amplified Photothermal Metalloimmunotherapy.  BIOMACROMOLECULES,      [PMID:40629961] [10.1021/acs.biomac.4c01774]
11. Zhuo Zhang, Mingchen Lv, Jiaxi Xu, Yaping Liu, Jinlong Qin, Zhen Fan, Jianzhong Du.  (2025)  A Metal-Peptide Framework as a Nanozyme for the Attenuation of Amyloid-β Aggregation and Reactive Oxygen Species.  JACS Au,      [PMID:41001643] [10.1021/jacsau.5c00721]
12. Wenjie Feng, Wanrui Shi, Shuwei Liu, Huiwen Liu, Yi Liu, Pengfei Ge, Hao Zhang.  (2021)  Fe(III)-Shikonin Supramolecular Nanomedicine for Combined Therapy of Tumor via Ferroptosis and Necroptosis.  Advanced Healthcare Materials,  11  (2): (2101926).  [PMID:34738742] [10.1002/adhm.202101926]
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