CALIDAD & PUREZAMoligand™?Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.≥99%
Moligand™, ≥99% Moligand™ para flujos de trabajo cromatográficos y analíticos sensibles que requieren una interferencia mínima de la línea base.
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Almacenamiento y envío
Store at -20°C Envío Ice chest + Ice pads. Consulte el COA específico del lote para conocer las especificaciones exactas.
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Documentos de calidad
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Prueba documental
Citado en 0 publicaciones revisadas por pares sobre cromatografía, síntesis orgánica y reacciones de acoplamiento cruzado.
Descripción general
EL-102 is a hypoxia-induced factor 1 (Hif1α) inhibitor. EL-102 induces apoptosis , inhibits tubulin polymerisation and shows activities against prostate cancer . EL-102 can be used for the research of cancer
In Vitro
EL-102 (0-120 nM; 72 h) inhibits prostate cancer cells proliferation in vitro. EL-102 (0-100 nM; 72 h) shows cytotoxicity to prostate cancer cell lines. EL-102 (10-100 nM; 24-72 h) induces cellular apoptosis and affects cell cycle. EL-102 (10-100 nM; 24-48 h) affects PARP cleavage in DU145 cells. EL-102 (5 nM; 0-60 min) inhibits tubulin polymerisation activity. EL-102 (0-100 nM; 1 hour) inhibits Hif1α protein expression. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: CWR22, 22Rv1, DU145, PC-3, DLKP and DLKPA cell lines Concentration: 0-120 nM Incubation Time: 72 hours Result: Inhibited proliferation of CWR22, 22Rv1, DU145, PC-3, DLKP and doxorubicin-selected variant DLKPA cells with IC 50 s of 24, 21.7, 40.3, 37.0, 14.4 and 16.3 nM, respectively. Cell Cytotoxicity AssayCell Line: CWR22, 22Rv1, DU145 and PC-3 cell lines Concentration: 0-100 nM Incubation Time: 72 hours Result: Exibited cytotoxicity to prostate cancer cell lines, and showed no additive effect on the inhibition of cell viability with docetaxel. Apoptosis AnalysisCell Line: CWR22, 22Rv1, DU145, PC-3, DLKP and DLKPA cell lines Concentration: 10 and 100 nM Incubation Time: 24, 48 and 72 hours Result: Induced cell apoptosis to inhibits cell viability with a dose of 100 nM. Western Blot AnalysisCell Line: DU145 cell line Concentration: 10 and 100 nM Incubation Time: 24 and 48 hours Result: Increased PARP cleavage in DU145 cells and showed a more dramatic effect with docetaxel adding. Cell Cycle AnalysisCell Line: DU145 cell line Concentration: 10 and 100 nM Incubation Time: 24, 48 and 72 hours Result: Increased loss of cells from G1 phase and accumulated cells in G2/M phase. Western Blot AnalysisCell Line: Prostate cancer cells Concentration: 10 , 50 and 100 nM Incubation Time: 24 and 48 hours Result: Modestly inhibited Hif1α expression at doses of 50 and 100 nM in normoxia.
In Vivo
EL-102 (12 and 15 mg/kg; p.o. 5-day on and 2-day off, from 13 to 37 days after tumour transplantation) potentiates effects of docetaxel in vivo . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Nude mice with CWR22 xenografts Dosage: 12 and 15 mg/kg Administration: Oral gavage; 12 and 15 mg/kg 5-day on and 2-day off; from 13 to 37 days after tumour transplantation Result: Showed no effect on tumor growth, but enhanced the effect of docetaxel on tumor .
EL-102 is a hypoxia-induced factor 1 (Hif1α) inhibitor. EL-102 induces apoptosis , inhibits tubulin polymerisation and shows activities against prostate cancer . EL-102 can be used for the research of cancer.
Condiciones de almacenamiento de almacenamiento
Store at -20°C
Enviado en
Ice chest + Ice pads
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
This compound belongs to the class of organic compounds known as benzenesulfonamides. These are organic compounds containing a sulfonamide group that is S-linked to a benzene ring.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
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