Emricasan (IDN-6556) - Moligand™, 10mM in DMSO , Caspase inhibitor, CAS No.254750-02-2, Caspase inhibitor

CAS: 254750-02-2 Cat. No.: E409139 Molecular Weight: 569.51

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

PF 03491390, PF-03491390 | L-​Alaninamide, N-​[2-​(1,​1-​dimethylethyl)​phenyl]​-​2-​oxoglycyl-​N-​[(1S)​-​1-​(carboxymethyl)​-​2-​oxo-​3-​(2,​3,​5,​6-​tetrafluorophenoxy)​propyl]​-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Emricasan (IDN-6556) Emricasan (IDN-6556, PF 03491390, PF-03491390) is a potent irreversible pan-caspase inhibitor. Emricasan is an inhibitor of Zika virus infection.
In vitro

Emricasan, also called IDN-6556 or PF-03491390, is an inhibitor of activated caspases, and it has sub- to nanomolar activity in vitro. Emricasan shows neuroprotective activity for hNPCs but does not suppress ZIKV replication.

In vivo

Emricasan decreases liver injury but not metabolic derangement in NASH. It also ameliorates inflammation. In the murine NASH model, stellate cell activation and hepatic fibrogenesis are attenuated by administration of the pan-caspase inhibitor Emricasan. Emricasan is currently being evaluated in phase 2 clinical trials for the reduction of hepatic injury and liver fibrosis caused by chronic HCV infection.
Cell Data

cell lines：

Concentrations：9 μM

Incubation Time：1 h

Powder Purity:≥98%

Specifications

Synonyms

PF 03491390, PF-03491390 | L-​Alaninamide, N-​[2-​(1, ​1-​dimethylethyl)​phenyl]​-​2-​oxoglycyl-​N-​[(1S)​-​1-​(carboxymethyl)​-​2-​oxo-​3-​(2, ​3, ​5, ​6-​tetrafluorophenoxy)​propyl]​-

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Emricasan (IDN-6556, PF 03491390, PF-03491390) is a potent irreversible pan-caspase inhibitor. Emricasan is an inhibitor of Zika virus infection.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Caspase inhibitor

Product Properties

• ALogP: 3.6

Names and Identifiers

• Isomeric SMILES: C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)COC1=C(C(=CC(=C1F)F)F)F)NC(=O)C(=O)NC2=CC=CC=C2C(C)(C)C
• Molecular Weight: 569.51
• Reaxy-Rn: 10047524
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=10047524&ln=

Associated Targets(Human)

CASP8 Tchem Caspase-8 (1 Activities)

Discover Target: CASP8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CASP3 Tchem Caspase-3 (1 Activities)

Discover Target: CASP3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 100 mg/mL (164.03 mM); Water: Insoluble; Ethanol: Insoluble