Escitalopram Oxalate - 10mM in DMSO , Serotonin transporter inhibitor, CAS No.219861-08-2, Serotonin transporter inhibitor

CAS: 219861-08-2 Cat. No.: E409043 Molecular Weight: 414.43 EC Number: 620-544-8 PubChem CID: 146571

GRADE & PURITY 10mM in DMSO

Synonyms

5-Isobenzofurancarbonitrile, 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-, (1S)-, ethanedioate (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Escitalopram Oxalate Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with K i of 0.89 nM.
In vitro

Escitalopram, the S-enantiomer of citalopram, belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). It is used to treat the depression associated with mood disorders. It is also used on occassion in the treatment of body dysmorphic disorder and anxiety. The antidepressant, antiobsessive-compulsive, and antibulimic actions of escitalopram are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin. In vitro studies show that escitalopram is a potent and selective inhibitor of neuronal serotonin reuptake and has only very weak effects on norepinephrine and dopamine neuronal reuptake. Escitalopram has no significant affinity for adrenergic (alpha1, alpha2, beta), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5HT1A, 5HT1B, 5HT2), or benzodiazepine receptors; antagonism of such receptors has been hypothesized to be associated with various anticholinergic, sedative, and cardiovascular effects for other psychotropic drugs. The chronic administration of escitalopram is found to downregulate brain norepinephrine receptors, as has been observed with other drugs effective in the treatment of major depressive disorder. Escitalopram does not inhibit monoamine oxidase.

In vivo

Cell Data

cell lines：H727 and BON

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

5-Isobenzofurancarbonitrile, 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1, 3-dihydro-, (1S)-, ethanedioate (1:1)

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with K_i of 0.89 nM.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Mechanism of action

Serotonin transporter inhibitor

Names and Identifiers

• Isomeric SMILES: CN(C)CCC[C@@]1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F.C(=O)(C(=O)O)O
• WGK Germany: 3
• Alternate CAS: 128196-01-0
• PubChem CID: 146571
• Molecular Weight: 414.43

Associated Targets(Human)

SLC6A4 Tclin Sodium-dependent serotonin transporter (1 Activities)

Discover Target: SLC6A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Specific Rotation[α]: 13° (C=1,MeOH)
• Melt Point(°C): 146 °C

References

1. Tiantian Wang, Ruihe Zheng, Song Sun.  (2022)  Drug Repurposing: Escitalopram attenuates acute lung injury by inhibiting the SIK2/ HDAC4/ NF-κB signaling cascade.  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,      [PMID:35158201] [10.1016/j.bbrc.2022.02.015]