Evifacotrep - 10mM in DMSO , CAS No.2413739-88-3

CAS: 2413739-88-3 Cat. No.: E656148 Fórmula: C₁₈H₁₂ClF₄N₅O₂ Peso molecular: 441.77 PubChem CID: 146448026

CALIDAD & PUREZA 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Evifacotrep, a short transient receptor potential channel 5 and 4 ( TRPC5 / TRPC4 ) antagonist (WO2020061162, compound 100), can be used for the research of neurological diseases. Evifacotrep targets to TRPC5 / TRPC4 with IC 50 s ≤50 nM

In Vitro

Evifacotrep (1 μM; 24 h) inhibits cell growth in ICLN-1694 cells(HEK-TRExhTRPC4). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Evifacotrep (30 mg/kg; sc; once daily or twice daily for 10 days) results in reduced urinary albumin excretion on following injury with puromycinaminonucleoside (PAN) . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:TRPC5

Especificaciones

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Evifacotrep, a short transient receptor potential channel 5 and 4 ( TRPC5 / TRPC4 ) antagonist (WO2020061162, compound 100), can be used for the research of neurological diseases. Evifacotrep targets to TRPC5 / TRPC4 with IC 50 s ≤50 nM.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

ANTAGONIST

Nombres e identificadores

Isómeros SMILES

C1CN(CC2=C1C(=NC=N2)OC3=C(C=C(C=C3)F)C(F)(F)F)C4=C(C(=O)NN=C4)Cl

PubChem CID

146448026

Peso molecular

441.77

Preguntas frecuentes

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2413739-88-3, the molecular formula is C18H12ClF4N5O2, and the molecular weight is 441.77 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.