GRADE & PURITYBioReagent?BioReagent grade — tested suitable for life-science and molecular-biology use. Use for cell culture, assays, and biochemical work needing biological compatibility.Native?Native grade — protein/biomolecule in its natural (non-recombinant, non-denatured) form. Use when native structure and activity are required.≥94%(SDS-PAGE)from Human plasma; Protein concentration: See COA
BioReagent, Native, ≥94%(SDS-PAGE), from Human plasma; Protein concentration: See COA BioReagent,Native for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -80°C,Avoid repeated freezing and thawing Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
Human Factor XIII is a tetramer composed of two pairs of chains held together by noncovalent bonds. After activation of the zymogen via Thrombin to its active enzyme form, Factor XIIIa is responsible for catalyzing the formation of covalent bridges between fibrin units to increase the elasticity of the clot network. The resulting cross-linked fibrin is very insoluble and resistant to lysis.
Buffer composition =50 mM Tris-HCl/0.1 M NaCl/1 mM EDTA/10u/mL aprotinin/20% glycerol/pH 7.5
Extinction Coefficient (1%)=13.8
Molecular Weight = 320,000 daltons
The human factor XIII is ≥94% as judged by SDS-PAGE. One plasma equivalent unit (PEU) is equal to ~108 Loewy units. The above protein was purified from Human plasma units that test negative for antibodies to HBc, HCV, HIV 1/2, HTLV-I/II, and non reactive for HBsAg, HIV-1 RNA, HCV RNA, HBV DNA and Syphilis by FDA approved tests. Donors are screened for CJD.
Specifications
Product Name
Factor XIII, CAS No.9013-56-3
Grade
BioReagent, Native
Specifications & Purity
BioReagent, Native, ≥94%(SDS-PAGE), from Human plasma; Protein concentration: See COA
Biochemical and Physiological Mechanisms
Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fib
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