Morphologic observation experiments on acute common hepatitis

Summary

This experiment is from the official website of the Fourth Military Medical University

Operation method

Morphologic observation experiments on acute common hepatitis

Materials and Instruments

Gross specimen Tissue section

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1. The lesions consist of extensive hepatocellular degeneration with slight necrosis in a punctate distribution.

2. Hepatocellular edema: the hepatocytes are enlarged and rounded, the cytoplasm becomes hollow and translucent, and some cells are 3 to 4 times larger than normal, which is called balloon-like change. Hepatocyte cords are disorganized and hepatic sinusoids are narrowed due to the enlargement of hepatocytes.

3. Eosinophilic hepatocytes: individual hepatocytes are eosinophilic with deep red coloration of the cytoplasm. In severe cases, the nucleus disappears and becomes a round deep red body, i.e. acidophilic body.

4. a few pitting necrotic areas scattered distribution, only 1 to several hepatocytes involved, necrotic hepatocytes have disappeared, and replaced by lymphocytes and phagocytes.

Caveat

Diagnostic points:1. extensive hydropic degeneration of hepatocytes;2. punctate necrosis;3. little inflammatory cell infiltration

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