Gastrodin - Moligand™,10mM in DMSO , CAS No.62499-27-8

CAS: 62499-27-8 Cat. No.: G408719 Fórmula: C₁₃H₁₈O₇ Peso molecular: 286.28 Número EC: 683-202-7

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Gastrodine | β-D-Glucopyranoside, 4-(hydroxymethyl)phenyl

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Gastrodin (Gastrodine), an anti-inflammatory polyphenol extracted from Chinese natural herbal Gastrodia elata Blume., benefits neurodegenerative diseases.
In vitro

Gastrodin is the most important and effective ingredient extracted from Chinese natural herbal Gastrodia elata. Gastrodin (30, 40, and 60 mM) significantly attenuates levels of neurotoxic proinflammatory mediators and proinflammatory cytokines by inhibition of the NF-kappaB signaling pathway and phosphorylation of MAPKs in LPS-stimulated microglial cells. However, It also upregulates the phosphatidylinositol 3-kinase (PI3-K)/Akt signaling, resulting in the inhibitory effects NF-kappaB and MAPKs activation in H9c2 cardiomyocytes.

In vivo

Gastrodin at 5 mg/kg can improve cycloheximide- and apomorphine-induced amnesia, but not scopolamine-induced acquisition impairment in rats. Thus, GAS can facilitate memory consolidation and retrieval, but not acquisition. LD50: Mice >1000mg/kg (i.v.)
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

Gastrodine | β-D-Glucopyranoside, 4-(hydroxymethyl)phenyl

Especificaciones y pureza

Moligand™,10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Gastrodin (Gastrodine), an anti-inflammatory polyphenol extracted from Chinese natural herbal Gastrodia elata Blume., benefits neurodegenerative diseases.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Nombres e identificadores

Isómeros SMILES

C1=CC(=CC=C1CO)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O

Peso molecular

286.28

Reaxy-Rn

25441801

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25441801&ln=

Propiedades químicas y físicas

• Rotación específica [α]: -66.0 to -70.0 deg(C=1,H2O)
• Punto de fusión (°C): 154-155°C