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· · COA & SDS Disponible para cada producto · Same-day shipping on in-stock items GDC-0068 - Moligand™, ≥98% , Serine/threonine-protein kinase AKT inhibitor, CAS No.1001264-89-6, Serine/threonine-protein kinase AKT inhibitor
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98% Synonyms
RG7440 | GDC0068 | GDC 0068 | RG-7440 | RG 7440 | DTXSID9041152 | Ipatasertib; GDC-0068 | NCGC00182063-03 | AS-17027 | 0RF | IPATASERTIB [WHO-DD] | (2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperaz
Storage
Almacenar a -20°C,cargado con argón
Shipped In
Hielera + almohadillas de hielo
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Why this grade Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Almacenar a -20°C,cargado con argón Ships Hielera + almohadillas de hielo Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general GDC-0068(RG 7440) es un inhibidor pan-Akt altamente selectivo dirigido a Akt1/2/3 con IC50 de 5 nM/18 nM/8 nM, 620 veces selectivo sobre PKA.
Specifications Sinónimos
RG7440 | GDC0068 | GDC 0068 | RG-7440 | RG 7440 | DTXSID9041152 | Ipatasertib; GDC-0068 | NCGC00182063-03 | AS-17027 | 0RF | IPATASERTIB [WHO-DD] | (2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperaz
Especificaciones y pureza
Moligand™, ≥98%
Mecanismos bioquímicos y fisiológicos
GDC-0068 es un nuevo inhibidor oral altamente selectivo, competitivo con ATP, diseñado para unirse a las 3 isoformas de Akt. GDC-0068 es un inhibidor pan-Akt altamente selectivo dirigido a Akt1, Akt2 y Akt3 con IC50 de 5 nM, 18 nM y 8 nM, respectivamente.
Condiciones de almacenamiento de almacenamiento
Almacenar a -20°C,cargado con argón
Enviado en
Hielera + almohadillas de hielo
Mecanismo de acción
Serine/threonine-protein kinase AKT inhibitor
Nota
Consulte la SDS para obtener más información ¿Necesita más consejos sobre solubilidad, uso y manipulación? Visite nuestra página de preguntas frecuentes (FAQ) para obtener más información.
Propiedades del producto Nombres e identificadores Pubchem Sid 528764581 Sonrisas canónicas CC1CC(C2=C1C(=NC=N2)N3CCN(CC3)C(=O)C(CNC(C)C)C4=CC=C(C=C4)Cl)O IUPAC Name (2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one InChIKey GRZXWCHAXNAUHY-NSISKUIASA-N INCHI 1S/C24H32ClN5O2/c1-15(2)26-13-19(17-4-6-18(25)7-5-17)24(32)30-10-8-29(9-11-30)23-21-16(3)12-20(31)22(21)27-14-28-23/h4-7,14-16,19-20,26,31H,8-13H2,1-3H3/t16-,19-,20-/m1/s1 Isómeros SMILES C[C@@H]1C[C@H](C2=C1C(=NC=N2)N3CCN(CC3)C(=O)[C@H](CNC(C)C)C4=CC=C(C=C4)Cl)O Peso molecular 458 Reaxy-Rn 29538777 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=29538777&ln=
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organoheterocyclic compounds Clase Diazinanes Subclass Piperazines Intermediate Tree Nodes Not available Direct Parent N-arylpiperazines Alternative Parents Beta amino acids and derivatives Phenylacetamides Dialkylarylamines Aminopyrimidines and derivatives Aralkylamines Chlorobenzenes Aryl chlorides Imidolactams Tertiary carboxylic acid amides Heteroaromatic compounds Secondary alcohols Dialkylamines Azacyclic compounds Organic oxides Carbonyl compounds Organochlorides Organopnictogen compounds Hydrocarbon derivatives Molecular Framework Aromatic heteropolycyclic compounds Substituents N-arylpiperazine - Beta amino acid or derivatives - Phenylacetamide - Dialkylarylamine - Halobenzene - Aminopyrimidine - Aralkylamine - Chlorobenzene - Monocyclic benzene moiety - Aryl halide - Imidolactam - Benzenoid - Aryl chloride - Pyrimidine - Heteroaromatic compound - Tertiary carboxylic acid amide - Carboxamide group - Amino acid or derivatives - Secondary alcohol - Azacycle - Secondary aliphatic amine - Carboxylic acid derivative - Secondary amine - Alcohol - Organohalogen compound - Organochloride - Organonitrogen compound - Carbonyl group - Organooxygen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Amine - Aromatic heteropolycyclic compound Descripción This compound belongs to the class of organic compounds known as n-arylpiperazines. These are organic compounds containing a piperazine ring where the nitrogen ring atom carries an aryl group. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Estructura 3D Objetivos asociados (humanos) Objetivos asociados (no humanos) Mecanismos de acción Certificados (CoA, COO, BSE/TSE y tabla de análisis) Propiedades químicas y físicas Solubilidad DMSO 92 mg/mL Water <1 mg/mL Ethanol 92 mg/mL Sensibilidad Moisture sensitive Peso molecular 458.000 g/mol XLogP3 2.500 Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 6 Rotatable Bond Count 6 Exact Mass 457.224 Da Monoisotopic Mass 457.224 Da Topological Polar Surface Area 81.600 Ų Heavy Atom Count 32 Formal Charge 0 Complexity 622.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 3 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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Reconstitution Calculator Reseñas Need help choosing the grade? Our grade selection guide covers purity, stabilizer status, and application suitability for all variants in our catalog.
View Moligand™ grade guide →
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