Gefapixant - Moligand™, 10mM in DMSO , Antagonist of P2X3, CAS No.1015787-98-0, Antagonist of P2X3
Disponible
SKU
G420321
P2 Receptor Antagonists
Information
Gefapixant Gefapixant (AF-219, MK-7264, R1646, RG-1646, RO 4926219) is an orally active small molecule antagonist of human P2X3 receptor with IC50 of about 30 nM, 100–250 nM for recombinant hP2X3 homotrimers and hP2X2/3 heterotrimeric receptors , respectively. Gefapixant has shown promise for the treatment of refractory and unexplained chronic cough.
Targets
hP2X3 (Cell-free assay); hP2X2/3 (Cell-free assay) 30 nM; 100-250 nM
Más Información
| CAS | 1015787-98-0 |
|---|---|
| Concentración | 10mM in DMSO |
| Sinónimos | 5-[(2,4-Diamino-5-pyrimidinyl)oxy]-4-isopropyl-2-methoxybenzenesulfonamide | AF9 | Lopac0_000838 | DB15097 | AC-35643 | Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)- | s6664 | Tox21_303065 | Gefapixant(AF-219,MK-7264) |
| Especificaciones y pureza | Moligand™, 10mM in DMSO |
| Condiciones de almacenamiento de almacenamiento | Store at -80°C |
| Enviado en | Dry ice packs + Cold packs |
| Product Description | Information Gefapixant Gefapixant (AF-219, MK-7264, R1646, RG-1646, RO 4926219) is an orally active small molecule antagonist of human P2X3 receptor with IC50 of about 30 nM, 100–250 nM for recombinant hP2X3 homotrimers and hP2X2/3 heterotrimeric receptors , respectively. Gefapixant has shown promise for the treatment of refractory and unexplained chronic cough. Targets hP2X3 (Cell-free assay); hP2X2/3 (Cell-free assay) 30 nM; 100-250 nM |
| Pubchem Sid | 528772219 |
| Objetivo | P2RX3 |
| Número CE | 823-334-6 |
| PubChem CID | 24764487 |
| Fórmula molecular | C14H19N5O4S |
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