GLXC-26326 - Moligand™, ≥98% , Inhibitor of ribosomal protein S6 kinase B1, CAS No.1226801-23-5, Inhibitor of ribosomal protein S6 kinase B1

CAS: 1226801-23-5 Cat. No.: G610596 Fórmula: C₂₅H₂₇F₄N₇O Peso molecular: 517.52 PubChem CID: 46186926

GRADE & PURITY Moligand™, ≥98%

Synonyms

example 45 [WO2010056563A1];GLXC26326;LY-2780301;LY2780301

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

LY2780301 is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor LY2780301 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway, thereby leading to inhibition of cell proliferation and the induction of apoptosis in tumor cells. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

Specifications

Sinónimos

example 45 [WO2010056563A1];GLXC26326;LY-2780301;LY2780301

Especificaciones y pureza

Moligand™, ≥98%

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Inhibitor of ribosomal protein S6 kinase B1

Pureza

≥98%

Nombres e identificadores

• Pubchem Sid: 528764613
• Sonrisas canónicas: CN(C)CCN1C=C(N=C1C2CCN(CC2)C3=NC=NC4=C3CC(=O)N4)C5=CC(=C(C=C5)F)C(F)(F)F
• InChIKey: YDFKZIGAUIKZGP-UHFFFAOYSA-N
• INCHI: 1S/C25H27F4N7O/c1-34(2)9-10-36-13-20(16-3-4-19(26)18(11-16)25(27,28)29)32-23(36)15-5-7-35(8-6-15)24-17-12-21(37)33-22(17)30-14-31-24/h3-4,11,13-15H,5-10,12H2,1-2H3,(H,30,31,33,37)
• Isómeros SMILES: CN(C)CCN1C=C(N=C1C2CCN(CC2)C3=NC=NC4=C3CC(=O)N4)C5=CC(=C(C=C5)F)C(F)(F)F
• PubChem CID: 46186926
• Peso molecular: 517.52

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Azoles
      • Subclass Imidazoles
        • Level5 Substituted imidazoles
          • Level6 Phenylimidazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Azoles
• Subclass: Imidazoles
• Intermediate Tree Nodes: Substituted imidazoles
• Direct Parent: Phenylimidazoles
• Alternative Parents: Trifluoromethylbenzenes Pyrrolopyrimidines 1,2,4-trisubstituted imidazoles Dialkylarylamines Aminopyrimidines and derivatives Fluorobenzenes Aryl fluorides Piperidines Imidolactams N-substituted imidazoles Heteroaromatic compounds Pyrroles Amino acids and derivatives Trialkylamines Lactams Secondary carboxylic acid amides Azacyclic compounds Hydrocarbon derivatives Alkyl fluorides Carbonyl compounds Organic oxides Organofluorides
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: 5-phenylimidazole - 4-phenylimidazole - Trifluoromethylbenzene - Pyrrolopyrimidine - 1,2,4-trisubstituted-imidazole - Dialkylarylamine - Trisubstituted imidazole - Fluorobenzene - Aminopyrimidine - Halobenzene - Aryl fluoride - Piperidine - Benzenoid - N-substituted imidazole - Monocyclic benzene moiety - Aryl halide - Imidolactam - Pyrimidine - Pyrrole - Heteroaromatic compound - Amino acid or derivatives - Lactam - Secondary carboxylic acid amide - Tertiary amine - Carboxamide group - Tertiary aliphatic amine - Carboxylic acid derivative - Azacycle - Organic nitrogen compound - Organohalogen compound - Organofluoride - Carbonyl group - Organonitrogen compound - Organooxygen compound - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Amine - Alkyl halide - Alkyl fluoride - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as phenylimidazoles. These are polycyclic aromatic compounds containing a benzene ring linked to an imidazole ring through a CC or CN bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

RPS6KB1 Tchem Ribosomal protein S6 kinase beta-1 (0 Activities)

Discover Target: RPS6KB1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)