GSK963 - Moligand™ , Inhibitor of receptor interacting serine/threonine kinase 1, CAS No.G610736, Inhibitor of receptor interacting serine/threonine kinase 1

CAS: G610736 Cat. No.: G610736 PubChem CID: 122703613

GRADE & PURITY Moligand™

Synonyms

GSK'963;GSK′963A

Storage

Room temperature

Specifications

Sinónimos

GSK'963;GSK′963A

Especificaciones y pureza

Moligand™

Condiciones de almacenamiento de almacenamiento

Room temperature

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Inhibitor of receptor interacting serine/threonine kinase 1

Nombres e identificadores

Sonrisas canónicas

O=C(C(C)(C)C)N1N=CC[C@H]1c1ccccc1

IUPAC Name

2,2-dimethyl-1-[(3S)-3-phenyl-3,4-dihydropyrazol-2-yl]propan-1-one

InChIKey

NJQVSLWJBLPTMD-LBPRGKRZSA-N

INCHI

1S/C14H18N2O/c1-14(2,3)13(17)16-12(9-10-15-16)11-7-5-4-6-8-11/h4-8,10,12H,9H2,1-3H3/t12-/m0/s1

Isómeros SMILES

CC(C)(C)C(=O)N1[C@@H](CC=N1)C2=CC=CC=C2

PubChem CID

122703613

Objetivos asociados (humanos)

RIPK1 Tchem Receptor-interacting serine/threonine-protein kinase 1 (6 Activities)

Discover Target: RIPK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABL1 Tclin Tyrosine-protein kinase ABL (18331 Activities)

Discover Target: ABL1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)

Discover Target: EGFR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

INSR Tclin Insulin receptor (5558 Activities)

Discover Target: INSR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ERBB2 Tclin Receptor protein-tyrosine kinase erbB-2 (7851 Activities)

Discover Target: ERBB2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PDGFRB Tclin Platelet-derived growth factor receptor beta (5195 Activities)

Discover Target: PDGFRB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IGF1R Tclin Insulin-like growth factor I receptor (8605 Activities)

Discover Target: IGF1R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KIT Tclin Stem cell growth factor receptor (10667 Activities)

Discover Target: KIT

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CSNK2A1 Tchem Casein kinase II alpha (3512 Activities)

Discover Target: CSNK2A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DAPK3 Tchem Death-associated protein kinase 3 (2108 Activities)

Discover Target: DAPK3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAPK11 Tchem MAP kinase p38 beta (2785 Activities)

Discover Target: MAPK11

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

LCK Tclin Tyrosine-protein kinase LCK (9212 Activities)

Discover Target: LCK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAPK14 Tchem MAP kinase p38 alpha (12866 Activities)

Discover Target: MAPK14

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GSK3B Tclin Glycogen synthase kinase-3 beta (11785 Activities)

Discover Target: GSK3B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PRKACB Tchem cAMP-dependent protein kinase beta-1 catalytic subunit (589 Activities)

Discover Target: PRKACB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PRKCZ Tchem Protein kinase C zeta (2414 Activities)

Discover Target: PRKCZ

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAP2K6 Tchem Dual specificity mitogen-activated protein kinase kinase 6 (1284 Activities)

Discover Target: MAP2K6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MYLK Tchem Myosin light chain kinase, smooth muscle (1267 Activities)

Discover Target: MYLK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CSNK1G1 Tchem Casein kinase I gamma 1 (2496 Activities)

Discover Target: CSNK1G1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FGFR2 Tclin Fibroblast growth factor receptor 2 (3405 Activities)

Discover Target: FGFR2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FGFR1 Tclin Fibroblast growth factor receptor 1 (9149 Activities)

Discover Target: FGFR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

STK3 Tchem Serine/threonine-protein kinase MST2 (3069 Activities)

Discover Target: STK3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CSNK1D Tchem Casein kinase I delta (4546 Activities)

Discover Target: CSNK1D

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CAMK2B Tchem CaM kinase II beta (1626 Activities)

Discover Target: CAMK2B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SRC Tclin Tyrosine-protein kinase SRC (10310 Activities)

Discover Target: SRC

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAP2K3 Tchem Dual specificity mitogen-activated protein kinase kinase 3 (632 Activities)

Discover Target: MAP2K3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHEK2 Tchem Serine/threonine-protein kinase Chk2 (4015 Activities)

Discover Target: CHEK2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PDPK1 Tchem 3-phosphoinositide dependent protein kinase-1 (3758 Activities)

Discover Target: PDPK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AKT2 Tchem Serine/threonine-protein kinase AKT2 (4301 Activities)

Discover Target: AKT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AKT3 Tchem Serine/threonine-protein kinase AKT3 (3157 Activities)

Discover Target: AKT3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GRK2 Tchem G-protein coupled receptor kinase 2 (1019 Activities)

Discover Target: GRK2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHUK Tchem Inhibitor of nuclear factor kappa B kinase alpha subunit (3170 Activities)

Discover Target: CHUK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IKBKB Tchem Inhibitor of nuclear factor kappa B kinase beta subunit (5554 Activities)

Discover Target: IKBKB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DAPK2 Tchem Death-associated protein kinase 2 (740 Activities)

Discover Target: DAPK2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AURKB Tchem Serine/threonine-protein kinase Aurora-B (6805 Activities)

Discover Target: AURKB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RPS6KA4 Tchem Ribosomal protein S6 kinase alpha 4 (2104 Activities)

Discover Target: RPS6KA4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ROCK1 Tclin Rho-associated protein kinase 1 (4723 Activities)

Discover Target: ROCK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PIM1 Tchem Serine/threonine-protein kinase PIM1 (9629 Activities)

Discover Target: PIM1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PKN2 Tchem Protein kinase N2 (1991 Activities)

Discover Target: PKN2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CSK Tchem Tyrosine-protein kinase CSK (2395 Activities)

Discover Target: CSK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

JAK3 Tclin Tyrosine-protein kinase JAK3 (8349 Activities)

Discover Target: JAK3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RPS6KA5 Tchem Ribosomal protein S6 kinase alpha 5 (3355 Activities)

Discover Target: RPS6KA5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PRKCE Tchem Protein kinase C epsilon (1520 Activities)

Discover Target: PRKCE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PRKCG Tchem Protein kinase C gamma (2471 Activities)

Discover Target: PRKCG

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PRKD3 Tchem Protein kinase C nu (2315 Activities)

Discover Target: PRKD3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PRKCI Tchem Protein kinase C iota (2821 Activities)

Discover Target: PRKCI

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PRKD1 Tchem Protein kinase C mu (1904 Activities)

Discover Target: PRKD1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RAF1 Tclin Serine/threonine-protein kinase RAF (4169 Activities)

Discover Target: RAF1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SYK Tclin Tyrosine-protein kinase SYK (7372 Activities)

Discover Target: SYK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PLK1 Tchem Serine/threonine-protein kinase PLK1 (28605 Activities)

Discover Target: PLK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ITK Tclin Tyrosine-protein kinase ITK/TSK (3699 Activities)

Discover Target: ITK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Objetivos asociados (no humanos)

Prkcd Protein kinase C delta (192 Activities)

Discover Target: Prkcd

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Prkcb Protein kinase C beta (2 Activities)

Discover Target: Prkcb

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mapk1 MAP kinase ERK2 (650 Activities)

Discover Target: Mapk1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Fgfr4 Fibroblast growth factor receptor 4 (138 Activities)

Discover Target: Fgfr4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Fgfr3 Fibroblast growth factor receptor 3 (21 Activities)

Discover Target: Fgfr3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Camk2g CaM kinase II gamma (1 Activities)

Discover Target: Camk2g

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Gck Hexokinase type IV (278 Activities)

Discover Target: Gck

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Tec Tyrosine-protein kinase TEC (25 Activities)

Discover Target: Tec

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

L929 (3802 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Peso molecular: 230.310 g/mol
• XLogP3: 2.100
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 230.142 Da
• Monoisotopic Mass: 230.142 Da
• Topological Polar Surface Area: 32.700 Ų
• Heavy Atom Count: 17
• Formal Charge: 0
• Complexity: 311.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Application Protocols

No vendor-validated protocols or application data are provided for this item.

General small-molecule handling protocol (for in vitro use; literature-level guidance):

• Stock preparation: Dissolve compound in anhydrous DMSO to 10–50 mM. Vortex and, if needed, warm gently (≤40 °C) or sonicate. Record exact concentration (weigh-by-difference, qNMR, or UV if chromophore known).
• Working solutions: Prepare serial dilutions in DMSO, then dilute into assay buffer/media to reach desired final concentrations with constant DMSO percentage across conditions.
• Controls: Include vehicle-only controls and, if available, an orthogonal compound or an inactive analog. Run at least 3 technical replicates per concentration.
• Storage of stocks: Aliquot to minimize freeze–thaw; protect from moisture and light as appropriate. Assess stability periodically by LC–MS or HPLC.

Item-specific tested applications, recommended concentrations, and positive controls: Not specified for this item; refer to CoA/Spec Sheet and relevant literature.

Biological Roles

This listing is for a research-use small molecule. Item-specific biological target(s), mode of action, and biochemical pathway interactions are not provided in the catalog record.

General guidance for small-molecule probes (literature-level, not item-specific):

• Such compounds are commonly used to modulate protein targets transiently, enabling pathway mapping, target validation, and phenotypic screening in cells and in vitro systems.
• Advantages over genetic perturbation include tunable dose/temporal control and reversible effects; however, off-target interactions and assay interference must be assessed.
• Best practices: confirm on-target engagement with orthogonal methods (e.g., CETSA, biochemical enzymology, target occupancy), include structural analog controls, and test across multiple cell lines/models to ensure generality.

No clinical/therapeutic use is claimed or implied. For any biological application, consult peer-reviewed literature on GSK963 (PubChem CID 122703613) and confirm identity/purity/specifications from the CoA prior to drawing mechanistic conclusions.

Buffer Applications

This product is not a buffering reagent. It does not form a defined conjugate acid–base pair for pH control in typical laboratory buffers.

Practical guidance for assay buffers (general):

• Prepare compound stocks in DMSO, then dilute into a suitable assay buffer (e.g., HEPES, PBS, Tris) while maintaining constant DMSO percentage across conditions.
• Maintain final DMSO at the lowest effective level (commonly ≤0.1–0.5% v/v) to minimize solvent effects on cells or enzymes.
• Filter buffers (0.22 µm) and include appropriate protein carriers/surfactants (e.g., 0.01–0.05% Tween-20 or 0.1% BSA) only if validated to avoid nonspecific adsorption or aggregation artifacts.

Item-specific pKa/solubility that would inform buffer choice: Not specified for this item; refer to CoA/Spec Sheet.

Green Alternatives

Because this item is a specific small-molecule probe rather than a solvent or commodity reagent, “green alternatives” refer primarily to greener handling and solvent choices during dissolution, storage, and analysis.

• Prefer greener solvents for analytical sample prep when compatible (e.g., EtOH, MeOH, water/MeCN mixes) instead of high-boiling dipolar aprotics.
• Minimize DMSO volumes by using the most concentrated stock feasible that maintains full dissolution and stability.
• Use miniaturized assay formats (96-/384-/1536-well) to reduce compound and solvent consumption.
• Apply vendor take-back or institutional hazardous waste programs to reduce environmental impact of expired stocks.

Illustrative comparison (general):

• DMSO vs DMF/NMP: DMSO typically offers a better EHS profile and is more acceptable in bioassays; choose DMSO first.
• MeCN vs chlorinated solvents for analytics: Where chromatographically feasible, prefer MeCN or alcohol/water systems over CH2Cl2/CHCl3.

Item-specific environmental metrics (biodegradability, Eco-tox, life-cycle data): Not specified for this item; refer to SDS or request supporting documentation if required by your EHS program.

Pharmaceutical Uses

This product is supplied strictly for research use only. It is not approved for human or veterinary use, nor for diagnostic or therapeutic applications.

Formulation-relevant notes (general, not item-specific):

• In early discovery, compounds are commonly handled as DMSO stocks for in vitro ADME/biology screening. For preformulation research, basic assessments may include solubility screening (pH/vehicles), chemical stability (stress: light, heat, oxidants), and permeability proxies (e.g., PAMPA; not performed or provided here).
• Excipients, dosage forms, and pharmacopeial monographs: Not applicable—no compendial status is indicated for this item.

Item-specific data such as polymorphs, salt forms, residual solvents, and stability-indicating methods: Not specified for this item; refer to CoA/Spec Sheet if available.

Physical Properties

Item-specific physicochemical data are not listed in this catalog record.

• Appearance: Not specified for this item; refer to CoA/Spec Sheet.
• Melting point: Not specified for this item; refer to CoA/Spec Sheet.
• Boiling point: Not applicable/unknown for a solid small molecule; refer to CoA/Spec Sheet.
• Density: Not specified for this item; refer to CoA/Spec Sheet.
• Solubility: Not specified for this item; refer to CoA/Spec Sheet. (General practice for screening compounds is dissolution in anhydrous DMSO to prepare concentrated stocks.)
• LogP/logD: Not specified for this item; refer to CoA/Spec Sheet.
• pKa: Not specified for this item; refer to CoA/Spec Sheet.
• Refractive index: Not applicable for a solid; refer to CoA/Spec Sheet if provided.

General guidance (literature-level, not item-specific):

• Small-molecule probe compounds are commonly supplied as crystalline solids or amorphous powders. For assay work, 10–50 mM DMSO stock solutions are typical, followed by dilution into aqueous assay buffers with ≤0.5% DMSO final to minimize vehicle effects.
• If aqueous solubility is limited, co-solvent systems (DMSO → buffer), gentle warming (≤40 °C), or sonication can aid dissolution; always filter through 0.22 µm for biophysical assays if particulate persists.

Quality and Grades

• Grade/Purity: Moligand™ (as provided)

What Moligand™ implies (general description):

• Moligand™ designates compounds intended for molecular screening, ligand discovery, and chemical biology applications. Such materials are typically provided with identity verification (e.g., NMR/LC–MS) suitable for research use. UV background, residual solvents, water, metal content, and other analytical attributes are controlled as appropriate for small-molecule libraries, but exact specifications are compound-specific.

Item-specific notes:

• Assay purity, water content, residual solvents, and chromophoric background: Not specified for this item; refer to CoA/Spec Sheet.
• Stabilizers/inhibitors: Not specified for this item; refer to CoA/Spec Sheet.

Practical guidance for users:

• For screening and SAR, verify identity and purity for your internal quality bar (e.g., LC–MS >95% area by UV at multiple wavelengths). If your application is sensitive to UV baseline or trace metals (biophysical assays, photochemical readouts), request or generate supporting analytics.
• If orthogonal analytics (qNMR, HRMS, chiral purity) are critical to your study, confirm with the CoA or perform in-house testing before use.

Reaction and Applications

This product is supplied as a research small molecule (Moligand™) intended primarily as a chemical probe/ligand for discovery and screening, not as a synthetic reagent.

• Synthetic reaction use: Not typically applicable. No item-specific roles in named reactions are provided in this listing.
• Analytical/assay applications (general): Suitable for biochemical binding studies, cell-based pathway interrogation, and SAR campaigns when used with appropriate controls and validated assay conditions.
• Formulation for assays: Prepare DMSO stocks under dry, clean conditions; confirm concentration by UV–vis or quantitative NMR when precise stoichiometry is important.
• Controls: Include vehicle (DMSO) controls and, where relevant, inactive analogs or orthogonal probes to deconvolute off-target or assay-interference effects.

If you intend to use this molecule as a building block or reagent:

• Verify functional group compatibility, stability, and purity via the CoA/Spec Sheet.
• Conduct small-scale feasibility tests to check for solvent compatibility, thermal stability, and chromatographic behavior before scale-up.

Reaction Conditions

Not typically applicable. This product is provided as a research small molecule for biological/biophysical studies rather than as a reagent for chemical synthesis.

If employing this molecule in any transformation (e.g., prodrug/salt formation, conjugation):

• Verify functional groups and stability from the CoA/Spec Sheet.
• Pilot small-scale reactions to assess solubility, thermal/oxidative sensitivity, and chromatographic behavior.
• Use anhydrous, oxygen-free conditions as warranted by the structure; many heteroaromatic probe compounds are stable under ambient conditions but can degrade under strong acid/base or high-temperature stress.

Item-specific reaction temperatures, catalysts, and yields: Not specified for this item; refer to CoA/Spec Sheet or primary synthesis literature for GSK963.

Safety and Handling

Hazard classification is not provided in this catalog record.

• GHS classification, signal word, hazard statements, and pictograms: Not specified for this item; refer to SDS.
• Primary hazards (general for research chemicals): May cause skin/eye irritation; avoid inhalation/ingestion. Handle as a potentially harmful laboratory chemical.
• PPE: Wear lab coat, safety glasses, and suitable chemical-resistant gloves. Use in a chemical fume hood to avoid exposure to dust or aerosols.
• Incompatibilities: Avoid strong oxidizers and strong acids/bases unless compatibility is known. Keep away from ignition sources if supplied with an organic solvent.
• First aid (general guidance—defer to SDS):
  • Inhalation: Move to fresh air; seek medical advice if symptoms persist.
  • Skin/eye contact: Rinse with plenty of water for at least 15 minutes; remove contaminated clothing.
  • Ingestion: Rinse mouth; seek medical attention.
• Spill response: Avoid dust formation; collect with inert absorbent; dispose according to institutional and local regulations.
• Waste: Treat as organic laboratory chemical waste; follow institutional hazardous waste procedures.

Always consult the product’s SDS for authoritative safety information before use.

Solvent Selection

This product is a small-molecule tool compound; item-specific solubility data are not listed.

General solvent guidance (screening/library compounds):

• Primary stock solvent: Anhydrous DMSO is the most common due to broad solubilizing power and assay compatibility at low final percentages.
• Secondary options: DMF, NMP, or mixtures (DMSO:H2O, DMSO:buffer) can help if DMSO alone is insufficient. For non-aqueous workflows, MeCN, MeOH, or EtOH may be considered.
• Aqueous use: Prepare a concentrated DMSO stock (e.g., 10–50 mM), then dilute into buffer with vigorous mixing to minimize precipitation. Keep final DMSO ≤0.1–0.5% v/v for most biochemical/cell-based assays.

Comparison (general):

• DMSO: highest solvency, low volatility; potential to affect membrane integrity above ~0.5–1%.
• DMF/NMP: strong solvency; higher concern for toxicity—use only if necessary and keep final assay levels very low.
• MeCN/MeOH/EtOH: volatile; lower solvency for highly lipophilic compounds but useful for analytical sample prep.

Item-specific solubility limits, partitioning (logP/logD), and pKa: Not specified for this item; refer to CoA/Spec Sheet.

Storage and Reconstitution

• Storage conditions (as provided): Room temperature.
• Shipped in: Not specified for this item; refer to CoA/Spec Sheet.
• Appearance: Not specified for this item; refer to CoA/Spec Sheet.

General best practices for small-molecule probes:

• Keep container tightly closed in a dry, well-ventilated place. Protect from excessive heat and direct light.
• If preparing solutions: make concentrated DMSO stocks (e.g., 10–50 mM), aliquot into inert, airtight vials (glass or compatible polymer), and store at −20 to −80 °C for long-term stability unless the CoA indicates alternative handling. Avoid repeated freeze–thaw; thaw on ice and keep capped to limit moisture ingress.
• Reconstitution: Use anhydrous DMSO initially; confirm full dissolution visually. For aqueous applications, dilute into buffer with vigorous mixing to avoid precipitation.

Item-specific stability, hygroscopicity, and solution shelf-life: Not specified for this item; refer to CoA/Spec Sheet and SDS.

Structure and Identity

• Product name: GSK963 (SKU: G610736)
• PubChem CID: 122703613 (literature identifier)
• CAS: Not specified for this item; refer to CoA/Spec Sheet.
• InChIKey: 240280 (as provided; format appears non-standard—refer to CoA/Spec Sheet for definitive identifier)
• Molecular formula: Not specified for this item; refer to CoA/Spec Sheet.
• Molecular weight: Not specified for this item; refer to CoA/Spec Sheet.
• SMILES: Not specified for this item; refer to CoA/Spec Sheet.

Structural features (general, literature-level, not item-specific):

• GSK963 is referenced in the chemical biology literature as a small-molecule tool compound. Specific ring systems, functional groups, and stereochemistry should be verified against the item’s CoA/Spec Sheet before use in structure-dependent applications.

2D structure description:

• Not provided for this catalog entry. Typical small-molecule tool compounds feature one or more aromatic/heteroaromatic rings, amide/urea/azole motifs, and hydrogen bond donor/acceptor elements; however, the exact framework for this item must be confirmed in the official specification documents.

Synthetic Utility

This catalog entry represents a finished small molecule intended as a probe/ligand for discovery experiments, not a general-purpose synthetic building block.

• Functional-group reactivity, protecting-group strategies, and named-reaction participation for this exact structure are not provided.
• If you intend to derivatize or immobilize the molecule, first confirm the presence and accessibility of modifiable handles (e.g., amine, carboxyl, phenol, halide) from the CoA/Spec Sheet or primary literature.
• For analytical and purification method development (general): reverse-phase HPLC with water/MeCN (0.1% formic acid) and LC–MS detection are commonly effective for small-molecule probes; verify UV maxima and ionization behavior experimentally.

Item-specific synthetic handles, coupling strategies, and stability data: Not specified for this item; refer to CoA/Spec Sheet.

Target Specificity

Item-specific biological target(s), binding constants, and selectivity profiles are not provided in this catalog record.

• Verified target, species reactivity, and on/off-target panels: Not specified for this item; refer to CoA/Spec Sheet and peer-reviewed literature.
• For research planning: incorporate orthogonal readouts and structure–activity relationship (SAR) controls to substantiate target engagement.

Note: No antibody/biologic attributes (clone, isotype, antigen) apply to this small-molecule product.