HA14-1 - 10mM in DMSO , CAS No.65673-63-4

CAS: 65673-63-4 Cat. No.: H408968 Fórmula: C₁₇H₁₇BrN₂O₅ Peso molecular: 409.23

GRADE & PURITY 10mM in DMSO

Synonyms

(R)-ethyl 2-amino-6-bromo-4-((R)-1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

HA14-1 is a non-peptidic ligand of aBcl-2surface pocket withIC50of ~9 μM.
In vitro

HA14-1 is a small molecule and nonpeptidic ligand of a Bcl-2 surface pocket with IC50 of approximately 9 μM. HA14-1 induces the apoptosis of HL-60 cells in a dose-dependent manner via caspase activation. HA14-1 shows cytotoxic effects on HF1A3, HF4.9 and HF28RA follicular lymphoma B cell lines with LC50 of 4.5 μM, 12.6 μM and 8.1 μM respectively. HA14-1 induces apoptosis of HF1A3, HF4.9 and HF28RA cells via caspase and ROS.

In vivo

HA14-1(400 nM) treatment did not have any significant effect on the growth of glioblastoma tumors in immunodeficient mice. But HA14-1 (400 nM) increases the effect of the DNA-damaging agent etoposide (2.5 mg/Kg) on glioblastoma growth in vivo.
Cell Data

cell lines：

Concentrations：~25 μM

Incubation Time：20 h

Powder Purity:

Specifications

Sinónimos

(R)-ethyl 2-amino-6-bromo-4-((R)-1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

HA14-1 is a non-peptidic ligand of a Bcl-2 surface pocket with IC50 of ~9 μM.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Nombres e identificadores

• Isómeros SMILES: CCOC(=O)C1=C(OC2=C(C1C(C#N)C(=O)OCC)C=C(C=C2)Br)N
• WGK Alemania: 3
• Peso molecular: 409.23
• Reaxy-Rn: 1405035
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1405035&ln=

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 32.5 mg/mL warmed with 50ºC Water: bath (100.16 mM); Water: Insoluble; Ethanol: Insoluble
• Índice de refracción: 1.57
• Punto de ebullición (°C): 535.1° C at 760 mmHg
• Punto de fusión (°C): 105-108°C

Preguntas frecuentes

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 65673-63-4, the molecular formula is C17H17BrN2O5, and the molecular weight is 409.23 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.