HDAC-IN-4 - ≥98% , CAS No.1252003-13-6

CAS: 1252003-13-6 Cat. No.: H649473 Fórmula: C₂₀H₂₂ClN₃O₂ Peso molecular: 371.87 PubChem CID: 91885505

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor with pIC 50 s of 7.2 and 6.8 in BRET assay, respectively. Antitumoral activity

In Vitro

HDAC-IN-4 inhibits HDAC1, HDAC2, HDAC3, HDAC8 and HDAC10 with pIC 50 s of 5.5, 4.6, 5.4, 5.4, 6.7 in FRET assay, respectively. HDAC-IN-4 is more potent against HDAC6 than Tubastatin A, suggests that HDAC-IN-4 may be a better HDAC6 probe than Tubastatin A. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:pIC50: 7.2 (HDAC6), and 6.8 (HDAC10)

Specifications

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor with pIC 50 s of 7.2 and 6.8 in BRET assay, respectively. Antitumoral activity.

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Pureza

≥98%

Nombres e identificadores

Sonrisas canónicas

CN1CCC2=C(C1)N(C3=CC=CC=C23)CC4=CC=C(C=C4)C(=O)NO.Cl

IUPAC Name

N-hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-9-yl)methyl]benzamide;hydrochloride

InChIKey

YKKFIADNEAJSEA-UHFFFAOYSA-N

INCHI

1S/C20H21N3O2.ClH/c1-22-11-10-17-16-4-2-3-5-18(16)23(19(17)13-22)12-14-6-8-15(9-7-14)20(24)21-25;/h2-9,25H,10-13H2,1H3,(H,21,24);1H

Isómeros SMILES

CN1CCC2=C(C1)N(C3=CC=CC=C23)CC4=CC=C(C=C4)C(=O)NO.Cl

PubChem CID

91885505

Peso molecular

371.87

Propiedades químicas y físicas

• Solubilidad: DMSO : 50 mg/mL (149.08 mM; ultrasonic and warming and heat to 60°C)

Preguntas frecuentes

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1252003-13-6, the molecular formula is C20H22ClN3O2, and the molecular weight is 371.87 g/mol. InChIKey YKKFIADNEAJSEA-UHFFFAOYSA-N.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.