Insulin(human), CAS No.11061-68-0

CAS: 11061-68-0 Cat. No.: I302196 Molecular Weight: 5807.57 EC Number: 234-279-7

GRADE & PURITY BioReagent

Overview

Recombinant Insulin, human, is produced in yeast and purified by standard chromatographic techniques. Insulin regulates blood glucose. In muscles and adipocytes it stimulates glucose intake and metabolism. It also controls the expression and various enzymes.

Insulin human has been used:

in the culture medium needed for the adipogenesis of ASCs (adipose-derived stem cells)

to study the effect of insulin in the young and aged brains of rats.

to study the effect of insulin on the inflammatory actions of protease-activated receptor 2 (PAR2) using mice model.

Product description

Human insulin is a polypeptide hormone secreted by pancreatic β-cells. Insulin plays a crucial role in numerous cellular activities, such as promoting the transport of glucose and amino acids, enhancing anabolism and reducing catabolism, stimulating cell growth, and more. Insulin is a common additive in serum-free mammalian cell culture media. Human insulin is produced through fermentation, separation, high-level purification, crystallization, and drying from Escherichia coli containing a gene that efficiently expresses human insulin. Human insulin is a protein consisting of 51 amino acid residues.

Purpose

It is only for R&D purposes and cannot be used for clinical treatment or consumption

Advantages and Specific

Ease of use: It can be dissolved directly using PBS, purified water, etc.

No animal-derived: Recombinant production, no exogenous viral contamination, and no use of any animal-derived raw materials in the production process.

Stable quality: Mass production ensures stable and continuous batch production; there is little difference between product batches, ensuring stable quality.

Specifications

Product Name

Insulin(human), CAS No.11061-68-0

Synonyms

Recombinant insulin Human

Grade

BioReagent

Specifications & Purity

BioReagent

Biochemical and Physiological Mechanisms

Endogenous insulin receptor agonist (Ki= 4.85 nM). Decreases plasma glucose levels, proteolysis, lipolysis and gluconeogenesis and increases glycogen and fatty acid synthesisin vivo.

CAS

11061-68-0

Molecule Type

Protein

Storage and Shipping

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic Polymers
    • Class Polypeptides

• Kingdom: Organic compounds
• Superclass: Organic Polymers
• Class: Polypeptides
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Polypeptides
• Alternative Parents: Cyclic peptides Hexacarboxylic acids and derivatives Tyrosine and derivatives Arginine and derivatives Phenylalanine and derivatives Histidine and derivatives Glutamic acid and derivatives Glutamine and derivatives Asparagine and derivatives Isoleucine and derivatives Leucine and derivatives Valine and derivatives Proline and derivatives N-acyl-alpha amino acids Alpha amino acid amides Amphetamines and derivatives Pyrrolidinecarboxamides N-acylpyrrolidines 1-hydroxy-2-unsubstituted benzenoids Beta hydroxy acids and derivatives Aralkylamines N-acyl amines Tertiary carboxylic acid amides Heteroaromatic compounds Imidazoles Primary carboxylic acid amides Guanidines Secondary carboxylic acid amides Organic disulfides Secondary alcohols Lactams Amino acids Azacyclic compounds Carboxylic acids Carboximidamides Carbonyl compounds Hydrocarbon derivatives Imines Monoalkylamines Organic oxides Organopnictogen compounds Primary alcohols
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Polypeptide - Hexacarboxylic acid or derivatives - Cyclic alpha peptide - Tyrosine or derivatives - Arginine or derivatives - Phenylalanine or derivatives - Histidine or derivatives - Glutamic acid or derivatives - Glutamine or derivatives - Asparagine or derivatives - Leucine or derivatives - Isoleucine or derivatives - N-acyl-alpha amino acid or derivatives - N-acyl-alpha-amino acid - Valine or derivatives - Proline or derivatives - Alpha-amino acid amide - Alpha-amino acid or derivatives - Amphetamine or derivatives - N-substituted-alpha-amino acid - N-acylpyrrolidine - Pyrrolidine carboxylic acid or derivatives - Pyrrolidine-2-carboxamide - Phenol - 1-hydroxy-2-unsubstituted benzenoid - Aralkylamine - Beta-hydroxy acid - N-acyl-amine - Fatty amide - Fatty acyl - Monocyclic benzene moiety - Hydroxy acid - Benzenoid - Heteroaromatic compound - Pyrrolidine - Azole - Tertiary carboxylic acid amide - Imidazole - Amino acid or derivatives - Amino acid - Guanidine - Lactam - Secondary carboxylic acid amide - Organic disulfide - Carboxamide group - Primary carboxylic acid amide - Secondary alcohol - Organoheterocyclic compound - Carboximidamide - Carboxylic acid - Azacycle - Carboxylic acid derivative - Alcohol - Imine - Primary aliphatic amine - Organonitrogen compound - Carbonyl group - Organooxygen compound - Primary alcohol - Primary amine - Hydrocarbon derivative - Organic oxide - Amine - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as polypeptides. These are peptides containing ten or more amino acid residues.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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