Ipratropium Bromide - 10mM in DMSO , CAS No.22254-24-6

CAS: 22254-24-6 Cat. No.: I408224 Fórmula: C₂₀H₃₀BrNO₃ Peso molecular: 412.37 Número EC: 244-873-8

GRADE & PURITY 10mM in DMSO

Synonyms

(3-​endo,​8-​syn)​-3-​(3-​hydroxy-​1-​oxo-​2-​phenylpropoxy)​-​8-​methyl-​8-​(1-​methylethyl)​-​8-​azoniabicyclo[3.2.1]​octane, bromide (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Ipratropium Bromide is an antagonist of M3 typemuscarinic acetylcholine receptors, used for the treatment of chronic obstructive pulmonary disease (COPD).
In vitro

Ipratropium bromide combined with Formoterol partially protects the lungs against the chronic inflammation and airspace enlargement by reducing neutrophilic infiltration possibly via the inhibition of MMP-9 activity. Ipratropium bromide (1 nM) significantly increases [Ca(2+)](i), decreases forward scatter and increases annexin-V-binding. Ipratropium bromide treatment is followed by slight but significant increase of hemolysis. Ipratropium bromide triggers suicidal erythrocyte death or eryptosis, an effect mainly due to stimulation of Ca(2+)-entry.

In vivo

Ipratropium dry powder inhalation (DPI) at a dose of 2400 mg/horse is an effective bronchodilator in these horses at rest but it has little effect on the airway calibre during the recovery period. Ipratropium significantly attenuates the lung lesions associated with parenchyma inflammatory cell influx and congestion observed in the cadmium treated rats. Ipratropium bromide partially protects the lungs against the inflammation by reducing neutrophilic infiltration. Ipratropium is an antagonist for pre-junctional muscarinic inhibitory receptors on pulmonary parasympathetic nerves and also confirms its potent antagonist actions on post-junctional muscarinic receptors in the airway smooth muscle in the guinea-pig. Ipratropium decreases the maximal change in pleural pressure during tidal breathing (delta Pplmax) and pulmonary resistance (RL) and increases dynamic compliance (Cdyn) in horse.
Cell Data

cell lines：J774.16 murine macrophage-like cell line

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

(3-​endo,​8-​syn)​-3-​(3-​hydroxy-​1-​oxo-​2-​phenylpropoxy)​-​8-​methyl-​8-​(1-​methylethyl)​-​8-​azoniabicyclo[3.2.1]​octane, bromide (1:1)

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Ipratropium Bromide is an antagonist of M3 type muscarinic acetylcholine receptors, used for the treatment of chronic obstructive pulmonary disease (COPD).

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Nombres e identificadores

• Isómeros SMILES: CC(C)[N+]1([C@@H]2CC[C@H]1CC(C2)OC(=O)C(CO)C3=CC=CC=C3)C.[Br-]
• Peso molecular: 412.37
• Reaxy-Rn: 6555591
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6555591&ln=

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 60 mg/mL (200.52 mM); Water: 60 mg/mL (200.52 mM); Ethanol: 2 mg/mL (6.68 mM)
• Punto de fusión (°C): 229-231°C

Preguntas frecuentes

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 22254-24-6, the molecular formula is C20H30BrNO3, and the molecular weight is 412.37 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.