ITH 12575 - ≥98% , CAS No.1802013-08-6

CAS: 1802013-08-6 Cat. No.: I287169 Molecular Weight: 331.86

GRADE & PURITY ≥98%

Synonyms

7-Chloro-1,5-dihydro-5-[2-(1-methylethyl)phenyl]-4,1-benzothiazepin-2(3H)-one

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

ITH-12575 is an inhibitor of Mitochondrial Na+/Ca2+ exchange (mNCX). ITH12575 reduces Ca(2+) influx through CALHM1 at low micromolar concentrations.

Specifications

Synonyms

7-Chloro-1, 5-dihydro-5-[2-(1-methylethyl)phenyl]-4, 1-benzothiazepin-2(3H)-one

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

ITH12575 is apotent and selective inhibitor of mitochondrial Na+/Ca2+ exchanger mNCX with neuroprotective activity. It was shown to reduce Ca2+ efflux from the mitochondria to the cytosol with an EC50 value of 690 nM and was shown to protect against Ca2+

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥98%

Names and Identifiers

• Canonical Smiles: CC(C)C1=CC=CC=C1C2C3=C(C=CC(=C3)Cl)NC(=O)CS2
• IUPAC Name: 7-chloro-5-(2-propan-2-ylphenyl)-1,5-dihydro-4,1-benzothiazepin-2-one
• InChIKey: RDMUJSJZBYAAEF-UHFFFAOYSA-N
• INCHI: 1S/C18H18ClNOS/c1-11(2)13-5-3-4-6-14(13)18-15-9-12(19)7-8-16(15)20-17(21)10-22-18/h3-9,11,18H,10H2,1-2H3,(H,20,21)
• Molecular Weight: 331.86
• Reaxy-Rn: 28321041
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=28321041&ln=

Chemical and Physical Properties

• Solubility: Solvent:DMSO, Max Conc. mg/mL: 33.19, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 6.64, Max Conc. mM: 20