JHU-083 - ≥99% , CAS No.1998725-11-3

CAS: 1998725-11-3 Cat. No.: J414248 Fórmula: C₁₄H₂₄N₄O₄ Peso molecular: 312.36

GRADE & PURITY ≥99%

Synonyms

Ethyl 2-(2-Amino-4-methylpentanamido)-DONL-​Norleucine,L-​leucyl-​6-​diazo-​5-​oxo-​,ethyl ester

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

Information

JHU-083 JHU-083 (Ethyl 2-(2-Amino-4-methylpentanamido)-DON) is a novel prodrug of DON.JHU-083 selectively blocks glutaminase activity in brain CD11b + cells and prevents depression-associated behaviors induced by chronic social defeat stress. Solutions are best fresh-prepared.

Targets

Glutaminase

In vitro

JHU-083 selectively inhibits T-cell proliferation and decreases T-cell activation, with no effect on DCs.

In vivo

orally administered JHU-083 significantly decreases the experimental autoimmune encephalomyelitis(EAE) severity in both prevention and treatment paradigms and reverses EAE-induced cognitive impairment.

Cell Research(from reference)

Cell lines：CD4⁺ T cells 

Concentrations：1 μM, 3 μM, 10 μM, 30 μM, or 100 μM 

Incubation Time：72h 

Specifications

Sinónimos

Ethyl 2-(2-Amino-4-methylpentanamido)-DONL-​Norleucine,L-​leucyl-​6-​diazo-​5-​oxo-​,ethyl ester

Especificaciones y pureza

≥99%

Mecanismos bioquímicos y fisiológicos

JHU-083 (Ethyl 2-(2-Amino-4-methylpentanamido)-DON) is a novel prodrug of DON.JHU-083 selectively blocks glutaminase activity in brain CD11b⁺ cells and prevents depression-associated behaviors induced by chronic social defeat stress.Solutions a

Condiciones de almacenamiento de almacenamiento

Protected from light,Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

ANTAGONIST

Pureza

≥99%

Nombres e identificadores

Sonrisas canónicas

CCOC(=O)C(CCC(=O)C=[N+]=[N-])NC(=O)C(CC(C)C)N

IUPAC Name

ethyl (2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-6-diazo-5-oxohexanoate

InChIKey

YZRCHOFKIPHQBW-RYUDHWBXSA-N

INCHI

1S/C14H24N4O4/c1-4-22-14(21)12(6-5-10(19)8-17-16)18-13(20)11(15)7-9(2)3/h8-9,11-12H,4-7,15H2,1-3H3,(H,18,20)/t11-,12-/m0/s1

Isómeros SMILES

CCOC(=O)[C@H](CCC(=O)C=[N+]=[N-])NC(=O)[C@H](CC(C)C)N

Peso molecular

312.36

Reaxy-Rn

29866752

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=29866752&ln=

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 62 mg/mL (198.48 mM); Water: 62 mg/mL (198.48 mM); Ethanol: 62 mg/mL (198.48 mM)

Preguntas frecuentes

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C, protected from light. The material is light-sensitive — keep it in its original opaque or amber container.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1998725-11-3, the molecular formula is C14H24N4O4, and the molecular weight is 312.36 g/mol. InChIKey YZRCHOFKIPHQBW-RYUDHWBXSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.